DISARM2 system

traitmech:000549 · CLASS · PROPOSED

A DISARM system in which an organism possesses a genome-encoded DefenseFinder DISARM_2 subtype locus represented by DISARM_2__drmE, DISARM_2__drmMII, DISARM__drmA, DISARM__drmB, and DISARM__drmC rule profiles.

Trait evidence (4)

DOI:10.1038/s41564-017-0051-0
Our results establish DISARM as a new defence system, providing protection against diverse phages

Ofir et al. experimentally established DISARM as a broad-spectrum phage defense system.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
| DISARM | 10\.1038/s41564-017-0051-0 | DISARM is a widespread bacterial defence system with broad anti-phage activities |

The pinned DefenseFinder article registry maps the DISARM source key to Ofir et al.'s DISARM phage-defense paper.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| DISARM__drmA | DISARM__drmA | DISARM | Custom | 90 | | DISARM__drmB | DISARM__drmB | DISARM | Custom | 90 | | DISARM__drmC | DISARM__drmC | DISARM | Custom | 40 | | DISARM_2__drmE | DISARM_2__drmE | DISARM_2 | Custom | 90 | | DISARM_2__drmMII | DISARM_2__drmMII | DISARM_2 | Custom | 90 |

The pinned DefenseFinder HMM inventory records the shared DISARM drmA, drmB, and drmC profiles and the DISARM_2 drmE and drmMII profiles.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
DISARM DISARM_2 4 4 DISARM_2__drmE, DISARM_2__drmMII, DISARM__drmA, DISARM__drmB, DISARM__drmC

The pinned DefenseFinder rules table models DISARM_2 as a DISARM subsystem requiring four profiles from DISARM_2__drmE, DISARM_2__drmMII, DISARM__drmA, DISARM__drmB, and DISARM__drmC.

DISARM2 loci support DISARM antiphage defense

Conservative system-level sketch linking a DISARM_2 locus to DISARM methyltransferase-associated phage defense and DISARM2 system possession.

NONMECHANISTIC · The graph captures DISARM2 at DefenseFinder subtype-locus level without asserting the exact DISARM2 effector chemistry, native host breadth, sensitive-phage breadth, whether every DefenseFinder DISARM_2 prediction is a complete experimentally active locus, or how the shared DISARM drmA, drmB, and drmC profiles combine with the DISARM_2 drmE and drmMII profiles.

Edge evidence

DISARM2 locus contributes to DISARM methyltransferase-associated antiphage defense RO:0002326
DISARM2 loci are represented in DefenseFinder by shared DISARM drmA, drmB, and drmC profiles plus DISARM_2-specific drmE and drmMII profiles.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | DISARM__drmA | DISARM__drmA | DISARM | Custom | 90 | | DISARM__drmB | DISARM__drmB | DISARM | Custom | 90 | | DISARM__drmC | DISARM__drmC | DISARM | Custom | 40 | | DISARM_2__drmE | DISARM_2__drmE | DISARM_2 | Custom | 90 | | DISARM_2__drmMII | DISARM_2__drmMII | DISARM_2 | Custom | 90 | The pinned DefenseFinder HMM inventory records the shared DISARM drmA, drmB, and drmC profiles and the DISARM_2 drmE and drmMII profiles.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv DISARM DISARM_2 4 4 DISARM_2__drmE, DISARM_2__drmMII, DISARM__drmA, DISARM__drmB, DISARM__drmC The pinned DefenseFinder rules table models DISARM_2 as a DISARM subsystem requiring four profiles from DISARM_2__drmE, DISARM_2__drmMII, DISARM__drmA, DISARM__drmB, and DISARM__drmC.
DISARM methyltransferase-associated antiphage defense confers DISARM2 system METPO:2007700
The first-pass DISARM2 system trait is realized by a DefenseFinder DISARM_2 subtype locus within the methyltransferase-associated DISARM family.
- DOI:10.1038/s41564-017-0051-0 Our results establish DISARM as a new defence system, providing protection against diverse phages Ofir et al. experimentally established DISARM as a broad-spectrum phage defense system.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | DISARM__drmA | DISARM__drmA | DISARM | Custom | 90 | | DISARM__drmB | DISARM__drmB | DISARM | Custom | 90 | | DISARM__drmC | DISARM__drmC | DISARM | Custom | 40 | | DISARM_2__drmE | DISARM_2__drmE | DISARM_2 | Custom | 90 | | DISARM_2__drmMII | DISARM_2__drmMII | DISARM_2 | Custom | 90 | The pinned DefenseFinder HMM inventory records the shared DISARM drmA, drmB, and drmC profiles and the DISARM_2 drmE and drmMII profiles.
DISARM2 system is a DISARM system rdfs:subClassOf
DISARM2 system possession is a DISARM-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md | DISARM | 10\.1038/s41564-017-0051-0 | DISARM is a widespread bacterial defence system with broad anti-phage activities | The pinned DefenseFinder article registry maps the DISARM source key to Ofir et al.'s DISARM phage-defense paper.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv DISARM DISARM_2 4 4 DISARM_2__drmE, DISARM_2__drmMII, DISARM__drmA, DISARM__drmB, DISARM__drmC The pinned DefenseFinder rules table models DISARM_2 as a DISARM subsystem requiring four profiles from DISARM_2__drmE, DISARM_2__drmMII, DISARM__drmA, DISARM__drmB, and DISARM__drmC.

Provenance

Identifier source: TraitMech local identifier
Definition source: https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv

Parent traits (1)

DISARM system traitmech:000211

Synonyms (6)

DISARM_2 RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
DISARM_2__drmE RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
DISARM_2__drmMII RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
DISARM__drmA RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
DISARM__drmB RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
DISARM__drmC RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve DISARM2 effector chemistry, exact native hosts, sensitive-phage breadth, shared-core component roles, and DISARM_2 profile-to-activity criteria before minting DISARM2 mechanism or component children.

KNOWLEDGE GAP OPEN disarm2-profile-activity-gap · raised by codex · 2026-10-02

Attached to causal_graphs#disarm2_locus_subtype_defense

Ofir et al. support DISARM as a broad antiphage-system family, and the pinned DefenseFinder HMM inventory and rules table support DISARM_2 as a subtype with drmE, drmMII, drmA, drmB, and drmC profiles. This first-pass record leaves exact DISARM2 effector chemistry, native host breadth, sensitive-phage breadth, shared-core component roles, and profile-to-activity requirements unresolved.

Evidence

DOI:10.1038/s41564-017-0051-0
Our results establish DISARM as a new defence system, providing protection against diverse phages
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| DISARM__drmA | DISARM__drmA | DISARM | Custom | 90 | | DISARM__drmB | DISARM__drmB | DISARM | Custom | 90 | | DISARM__drmC | DISARM__drmC | DISARM | Custom | 40 | | DISARM_2__drmE | DISARM_2__drmE | DISARM_2 | Custom | 90 | | DISARM_2__drmMII | DISARM_2__drmMII | DISARM_2 | Custom | 90 |
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
DISARM DISARM_2 4 4 DISARM_2__drmE, DISARM_2__drmMII, DISARM__drmA, DISARM__drmB, DISARM__drmC

Curation history

2026-10-02T15:56:12Z · MINTED_TRAITMECH_ID · codex
Minted DISARM2 system as a DOI- and DefenseFinder-backed GENOMICS TraitRecord under the DISARM system parent after an ignored-and-hidden duplicate review found no exact live DISARM2 TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v426.
2026-10-02T15:56:13Z · REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP · codex
Reviewed DISARM2 system during initial curation and left canonical_examples empty because Ofir et al. and the pinned DefenseFinder tables support the DISARM family and the DISARM_2 model namespace but not an accession-backed native microbial taxon exemplar tied to DISARM_2 profiles and experimentally verified endogenous DISARM2 activity. No paid research was used.