Dodola system

traitmech:000252 · CLASS · PROPOSED

A phage defense system in which an organism possesses a two-component Dodola locus represented by DolA and DolB profiles that can protect bacteria from bacteriophage infection.

Trait evidence (6)

DOI:10.1016/j.chom.2022.09.017
discovery of 21 defense systems that protect bacteria from phages, based on computational genomic analyses and phage-infection experiments

Millman et al. report the computational and experimental cohort that DefenseFinder cites for Dodola as a bacterial anti-phage system.
DOI:10.1101/2022.05.11.491447
discovery of 21 new defense systems that protect bacteria from phages, based on computational genomic analyses and phage infection experiments

The bioRxiv version of Millman et al. independently carries the 21-system discovery claim linked from DefenseFinder's Dodola article registry.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
Dodola | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages

The DefenseFinder model registry maps the named Dodola system to the Millman et al. antiphage-system discovery preprint.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
Dodola Dodola 2 2 Dodola__DolA, Dodola__DolB

The DefenseFinder rules table models Dodola as a two-component system with DolA and DolB as mandatory profile choices.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Dodola__DolA | Dodola__DolA | Dodola

The DefenseFinder HMM inventory records DolA as a Dodola profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Dodola__DolB | Dodola__DolB | Dodola

The DefenseFinder HMM inventory records DolB as a Dodola profile.

Dodola loci confer bacterial phage defense

Conservative system-level sketch linking possession of a Dodola locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures Dodola as a named anti-phage system with DefenseFinder DolA and DolB profiles while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved.

Edge evidence

Dodola locus contributes to restricted phage propagation RO:0002326
DefenseFinder maps Dodola to a bacterial anti-phage-system discovery preprint and represents Dodola loci through DolA and DolB component profiles.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. describe the anti-phage discovery cohort that the DefenseFinder Dodola registry row maps to the Dodola system.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Dodola | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages The DefenseFinder registry maps Dodola itself to the Millman et al. bacterial antiphage-system discovery preprint.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv Dodola Dodola 2 2 Dodola__DolA, Dodola__DolB The DefenseFinder rules table supports DolA and DolB as Dodola system profile choices.
restricted phage propagation confers Dodola system METPO:2007700
Dodola-mediated phage restriction realizes the Dodola system trait.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. place the Dodola discovery cohort in the set of bacterial systems that protect against phages.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Dodola | 10\.1101/2022\.05\.11\.491447 | An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder records Dodola as a named system from the Millman et al. antiphage discovery preprint.
Dodola system is a phage defense system rdfs:subClassOf
Dodola system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md An expanding arsenal of immune systems that protect bacteria from phages DefenseFinder associates Dodola with the Millman et al. bacterial antiphage-system discovery paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.chom.2022.09.017

Parent traits (1)

phage defense system traitmech:000209

Synonyms (1)

Dodola EXACT_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Dodola phage triggers and effector outputs before minting narrower Dodola mechanism children.

KNOWLEDGE GAP OPEN dodola-mechanism-gap · raised by codex · 2026-09-18

Attached to causal_graphs#dodola_locus_restricts_phage

Millman et al. and DefenseFinder support Dodola as a named anti-phage system with DolA and DolB profiles, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-18T21:38:00Z · MINTED_TRAITMECH_ID · codex
Minted Dodola system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v129.