TraitMech

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Lamassu-FMO system

traitmech:000558 · CLASS · PROPOSED

A Lamassu system in which an organism possesses a genome-encoded DefenseFinder Lamassu-FMO subtype locus represented by the Lamassu-FMO rule row requiring the Lamassu-Fam__LmuA_effector_FMO and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II profiles.

Trait evidence (8)

Lamassu-FMO is a DefenseFinder Lamassu subtype

Conservative subtype-level classification linking the DefenseFinder Lamassu-FMO rule-row definition to Lamassu-FMO system possession and its Lamassu parent.

NONMECHANISTIC · The graph captures Lamassu-FMO as a DefenseFinder rule-row subtype of Lamassu system possession without asserting a Lamassu-FMO-specific antiphage process, expanding the FMO profile name, selecting between the rule-row LmuB/LmuC profiles and the FMO-scoped HMM rows, or resolving exact phage-triggered substrate chemistry, viral-DNA trigger, LmuC requirement, native host breadth, cell-death output, or whether every DefenseFinder Lamassu-FMO prediction is a complete experimentally active locus.

Lamassu-FMO is a DefenseFinder Lamassu subtype Interactive directed graph showing evidence-backed causal relationships for Lamassu-FMO system.

Edge evidence

Provenance

Identifier source
TraitMech local identifier
Definition source
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv

Parent traits (1)

Synonyms (2)

  • Lamassu-FMO RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
  • Lamassu-Fam__LmuA_effector_FMO RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Lamassu-FMO phage triggers, native hosts, FMO effector meaning, LmuB/LmuC model rows, LmuC usage, and profile-to-activity criteria before minting enzyme, trigger, or component children.

KNOWLEDGE GAP OPEN lamassu-fmo-activity-gap · raised by codex · 2026-10-02

Attached to causal_graphs#lamassu_fmo_locus_subtype_defense

Haudiquet et al. support a Lamassu family with diverse LmuA effectors and a conserved SMC-like sensor, and the pinned DefenseFinder HMM inventory and rules table support Lamassu-FMO as a Lamassu-Fam subtype whose rule row requires Lamassu-Fam__LmuA_effector_FMO and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II. This first-pass record follows the rule row but leaves the relationship between its LmuB/LmuC Cap4-nuclease/Lipase profile names and the FMO-scoped Lamassu-Fam__LmuB_SMC_FMO and Lamassu-Fam__LmuC_acc_FMO HMM rows unresolved, along with exact FMO expansion and substrate chemistry, LmuC requirement, native hosts, phage triggers, cell-death output, and profile-to-activity criteria.

Evidence

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Minted Lamassu-FMO system as a DefenseFinder-backed GENOMICS TraitRecord under the Lamassu system parent after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record for the target local ID, placeholder METPO ID, proposal cohort, record slug, human label, DefenseFinder subsystem, or LmuA FMO profile string; the replacement placeholder is reserved in proposals/metpo_traitmech_v435.

  2. · REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP · codex

    Reviewed Lamassu-FMO system during initial curation and left canonical_examples empty because the pinned DefenseFinder tables support a rule-row subtype but not an accession-backed native microbial taxon exemplar tied to the Lamassu-FMO profiles and experimentally verified endogenous activity. No paid research was used.