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Lamassu-Hydrolase system

traitmech:000561 · CLASS · PROPOSED

A Lamassu system in which an organism possesses a genome-encoded DefenseFinder Lamassu-Hydrolase subtype locus represented by the Lamassu-Hydrolase rule row requiring the Lamassu-Fam__LmuA_effector_Hydrolase and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II profiles.

Trait evidence (6)

Lamassu-Hydrolase is a DefenseFinder Lamassu subtype

Conservative subtype-level classification linking the DefenseFinder Lamassu-Hydrolase rule-row definition to Lamassu-Hydrolase system possession and its Lamassu parent.

NONMECHANISTIC · The graph captures Lamassu-Hydrolase as a DefenseFinder rule-row subtype of Lamassu system possession without asserting a Lamassu-Hydrolase-specific antiphage process, exact phage-triggered substrate chemistry, viral-DNA trigger, LmuC requirement, native host breadth, cell-death output, or whether every DefenseFinder Lamassu-Hydrolase prediction is a complete experimentally active locus.

Lamassu-Hydrolase is a DefenseFinder Lamassu subtype Interactive directed graph showing evidence-backed causal relationships for Lamassu-Hydrolase system.

Edge evidence

Provenance

Identifier source
TraitMech local identifier
Definition source
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv

Parent traits (1)

Synonyms (2)

  • Lamassu-Hydrolase RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
  • Lamassu-Fam__LmuA_effector_Hydrolase RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Lamassu-Hydrolase phage triggers, native hosts, hydrolase effector substrates, LmuC usage, and profile-to-activity criteria before minting enzyme, trigger, or component children.

KNOWLEDGE GAP OPEN lamassu-hydrolase-activity-gap · raised by codex · 2026-10-03

Attached to causal_graphs#lamassu_hydrolase_locus_subtype_defense

Haudiquet et al. support a Lamassu family with diverse LmuA effectors and a conserved SMC-like sensor, and the pinned DefenseFinder HMM inventory and rules table support Lamassu-Hydrolase as a Lamassu-Fam subtype whose rule row requires Lamassu-Fam__LmuA_effector_Hydrolase and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II. This first-pass record follows the rule row but leaves exact hydrolase substrates, LmuC requirement, native hosts, phage triggers, cell-death output, and profile-to-activity criteria unresolved.

Evidence

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Minted Lamassu-Hydrolase system as a DefenseFinder-backed GENOMICS TraitRecord under the Lamassu system parent after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record for the target local ID, placeholder METPO ID, proposal cohort, record slug, human label, or DefenseFinder subsystem; existing Lamassu-Fam__LmuA_effector_Hydrolase mentions were limited to forbidden-profile evidence on neighboring Lamassu-Fam subtypes, and the replacement placeholder is reserved in proposals/metpo_traitmech_v438.

  2. · REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP · codex

    Reviewed Lamassu-Hydrolase system during initial curation and left canonical_examples empty because the pinned DefenseFinder tables support a rule-row subtype but not an accession-backed native microbial taxon exemplar tied to the Lamassu-Hydrolase profiles and experimentally verified endogenous activity. No paid research was used.