TraitMech

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Lamassu-Mrr system

traitmech:000563 · CLASS · PROPOSED

A Lamassu system in which an organism possesses a genome-encoded DefenseFinder Lamassu-Mrr subtype locus represented by the Lamassu-Mrr rule row requiring the Lamassu-Fam__LmuA_effector_Mrr and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II profiles.

Trait evidence (8)

Lamassu-Mrr is a DefenseFinder Lamassu subtype

Conservative subtype-level classification linking the DefenseFinder Lamassu-Mrr rule-row definition to Lamassu-Mrr system possession and its Lamassu parent.

NONMECHANISTIC · The graph captures Lamassu-Mrr as a DefenseFinder rule-row subtype of Lamassu system possession without asserting a Lamassu-Mrr-specific antiphage process, selecting between the rule-row LmuB/LmuC profile names and the Mrr-scoped LmuB/LmuC HMM rows, or resolving exact phage-triggered Mrr effector activity, viral-DNA trigger, LmuC requirement, native host breadth, cell-death output, or whether every DefenseFinder Lamassu-Mrr prediction is a complete experimentally active locus.

Lamassu-Mrr is a DefenseFinder Lamassu subtype Interactive directed graph showing evidence-backed causal relationships for Lamassu-Mrr system.

Edge evidence

Provenance

Identifier source
TraitMech local identifier
Definition source
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv

Parent traits (1)

Synonyms (2)

  • Lamassu-Mrr RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
  • Lamassu-Fam__LmuA_effector_Mrr RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Lamassu-Mrr phage triggers, native hosts, Mrr effector activity, LmuB/LmuC model rows, LmuC usage, and profile-to-activity criteria before minting enzyme, trigger, or component children.

KNOWLEDGE GAP OPEN lamassu-mrr-activity-gap · raised by codex · 2026-10-03

Attached to causal_graphs#lamassu_mrr_locus_subtype_defense

Haudiquet et al. support a Lamassu family with diverse LmuA effectors and a conserved SMC-like sensor, and the pinned DefenseFinder HMM inventory and rules table support Lamassu-Mrr as a Lamassu-Fam subtype whose rule row requires Lamassu-Fam__LmuA_effector_Mrr and Lamassu-Fam__LmuB_SMC_Cap4_nuclease_II. This first-pass record follows the rule row but leaves the relationship between its LmuB Cap4-nuclease and LmuC Lipase profile names and the Mrr-scoped Lamassu-Fam__LmuB_SMC_Mrr and Lamassu-Fam__LmuC_acc_Mrr HMM rows unresolved, along with exact Mrr effector activity, LmuC requirement, native hosts, phage triggers, cell-death output, and profile-to-activity criteria.

Evidence

Curation history

  1. · MINTED_TRAITMECH_ID · codex

    Minted Lamassu-Mrr system as a DefenseFinder-backed GENOMICS TraitRecord under the Lamassu system parent after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record for the target local ID, placeholder METPO ID, proposal cohort, record slug, human label, or DefenseFinder subsystem; existing Lamassu-Fam__LmuA_effector_Mrr mentions were limited to forbidden-profile evidence on neighboring Lamassu-Fam subtypes, and the replacement placeholder is reserved in proposals/metpo_traitmech_v440.

  2. · REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP · codex

    Reviewed Lamassu-Mrr system during initial curation and left canonical_examples empty because the pinned DefenseFinder tables support a rule-row subtype but not an accession-backed native microbial taxon exemplar tied to the Lamassu-Mrr profiles and experimentally verified endogenous activity. No paid research was used.