lanthivirin system

traitmech:000416 · CLASS · PROPOSED

A phage defense system in which an organism possesses a lanthivirin lanthipeptide biosynthetic gene cluster that can confer anti-phage activity in a native Streptomyces context and after heterologous expression of complete lanthivirin systems.

Trait evidence (6)

DOI:10.1016/j.chom.2026.06.017
We demonstrate anti-phage activity both in a native Streptomyces context and through heterologous expression of six distinct lanthivirin systems.

Serra et al. support native Streptomyces anti-phage activity and activity from multiple heterologously expressed lanthivirin systems.
DOI:10.1016/j.chom.2026.06.017
lanthivirin maturation is required for anti-phage activity

Serra et al. support the requirement for lanthivirin maturation in anti-phage activity.
DOI:10.1016/j.chom.2026.06.017
phage-protein-dependent inhibition of phage DNA replication

Serra et al. link lanthivirins to inhibition of phage DNA replication.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
| Lanthiphage | 10\.1101/2024\.06\.26\.600839 | A family of lanthipeptides with anti-phage function |

The pinned DefenseFinder article registry maps the Lanthiphage source key to the lanthipeptide anti-phage preprint.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Lanthiphage__LphA |

The pinned DefenseFinder HMM inventory records Lanthiphage__LphA as a custom Lanthiphage profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Lanthiphage__LphB1 |

The pinned DefenseFinder HMM inventory records Lanthiphage__LphB1 as a custom Lanthiphage profile.

Lanthivirin BGCs mediate anti-phage activity

Conservative system-level sketch linking possession of a lanthivirin biosynthetic gene cluster to anti-phage activity and lanthivirin system possession.

NONMECHANISTIC · The graph captures lanthivirins at the biosynthetic gene cluster and anti-phage-output level without asserting the full native host range, exact Lanthiphage profile-to-component model, complete phage target breadth, or a DefenseFinder detection rule absent from the pinned rules table.

Edge evidence

lanthivirin biosynthetic gene cluster enables lanthivirin maturation RO:0002327
A lanthivirin biosynthetic gene cluster encodes the machinery required for lanthivirin maturation.
- DOI:10.1016/j.chom.2026.06.017 lanthivirin maturation is required for anti-phage activity Serra et al. support the requirement for lanthivirin maturation in anti-phage activity.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | Lanthiphage__LphA | The pinned DefenseFinder HMM inventory records Lanthiphage__LphA as a custom Lanthiphage profile.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md | Lanthiphage__LphB1 | The pinned DefenseFinder HMM inventory records Lanthiphage__LphB1 as a custom Lanthiphage profile.
lanthivirin maturation mitigates phage DNA replication METPO:2007407
Mature lanthivirins are associated with a phage-protein-dependent inhibition of phage DNA replication.
- DOI:10.1016/j.chom.2026.06.017 phage-protein-dependent inhibition of phage DNA replication Serra et al. link lanthivirins to inhibition of phage DNA replication.
lanthivirin maturation confers lanthivirin system METPO:2007700
Lanthivirin maturation realizes the anti-phage activity of the lanthivirin system.
- DOI:10.1016/j.chom.2026.06.017 We demonstrate anti-phage activity both in a native Streptomyces context and through heterologous expression of six distinct lanthivirin systems. Serra et al. support native Streptomyces anti-phage activity and activity from multiple heterologously expressed lanthivirin systems.
lanthivirin system is a phage defense system rdfs:subClassOf
Lanthivirin system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md | Lanthiphage | 10\.1101/2024\.06\.26\.600839 | A family of lanthipeptides with anti-phage function | The pinned DefenseFinder article registry maps the Lanthiphage source key to the lanthipeptide anti-phage preprint.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.chom.2026.06.017

Parent traits (1)

phage defense system traitmech:000209

Synonyms (2)

lanthivirin BGC RELATED_SYNONYM · DOI:10.1016/j.chom.2026.06.017
Lanthiphage RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Lanthiphage HMM-to-component coverage, rule-level detection criteria, sensitive-phage breadth, and exact lanthivirin effector identity before minting narrower lanthivirin mechanism children.

KNOWLEDGE GAP OPEN lanthivirin-defensefinder-model-gap · raised by codex · 2026-09-27

Attached to causal_graphs#lanthivirin_bgc_inhibits_phage_dna_replication

Serra et al. support lanthivirin biosynthetic gene clusters as anti-phage systems, and the pinned DefenseFinder HMM inventory records Lanthiphage profile rows. The pinned rules table has no Lanthiphage row, and the first-pass record does not yet resolve exact profile-to-component mapping, full native host breadth, phage target breadth, or the direct mature lanthivirin effector.

Evidence

DOI:10.1016/j.chom.2026.06.017
We demonstrate anti-phage activity both in a native Streptomyces context and through heterologous expression of six distinct lanthivirin systems.
DOI:10.1016/j.chom.2026.06.017
lanthivirin maturation is required for anti-phage activity
DOI:10.1016/j.chom.2026.06.017
phage-protein-dependent inhibition of phage DNA replication
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
| Lanthiphage | 10\.1101/2024\.06\.26\.600839 | A family of lanthipeptides with anti-phage function |
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Lanthiphage__LphA |
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
| Lanthiphage__LphB1 |
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv

Curation history

2026-09-27T20:02:44Z · MINTED_TRAITMECH_ID · codex
Minted lanthivirin system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; kept the graph at lanthipeptide biosynthetic-gene-cluster level because the pinned DefenseFinder HMM rows are not backed by pinned rules rows; the replacement placeholder is reserved in proposals/metpo_traitmech_v293.
2026-09-27T20:02:45Z · REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP · codex
Reviewed lanthivirin system during canonical-example issue 444 enforcement and left canonical_examples empty because the sources support Streptomyces-context and heterologous expression assays, plus DefenseFinder Lanthiphage HMM rows, but not a direct named native microbial isolate exemplar with experimentally verified endogenous lanthivirin activity. No paid research was used.