MMB gp29-gp30 system

traitmech:000297 · CLASS · PROPOSED

A phage defense system in which an organism possesses an MMB gp29-gp30 locus that can protect bacteria from bacteriophage infection.

Trait evidence (10)

DOI:10.1038/nmicrobiol.2016.251
at least five distinct prophage-expressed viral defense systems that interfere with infection

The PMC author manuscript for Dedrick et al. places the Cluster N MMB gp29-gp30 system in a cohort of prophage-expressed defenses against lytic and temperate mycobacteriophages.
DOI:10.1038/nmicrobiol.2016.251
Tweety (F1) is targeted by Xerxes, MMB, Phrann and Panchino

The PMC author manuscript for Dedrick et al. identifies Tweety as one phage targeted by the MichelleMyBell prophage defense profile.
DOI:10.1038/nmicrobiol.2016.251
Phages MMB, Xerxes, and Pipsqueaks are closely-related in the lysis-immunity region (Fig. 4a) and MMB and Xerxes have almost identical patterns of defense against eleven individual phages

The PMC author manuscript for Dedrick et al. connects the MichelleMyBell and Xerxes defense spectra to their shared lysis-immunity-region context.
DOI:10.1038/nmicrobiol.2016.251
we constructed a MMB mutant in which genes 29 and 30 are removed (deletions of individual genes appear to generate non-viable mutants; Supplementary Table 3) and showed that prophage-mediated defense is lost

The PMC author manuscript for Dedrick et al. deletes the MMB 29-30 interval when testing whether gp29 and gp30 contribute to MMB defense.
DOI:10.1038/nmicrobiol.2016.251
expressing MMB 29 and 30 confers the same pattern of defense as the MMB lysogen

The PMC author manuscript for Dedrick et al. shows that recombinant MMB genes 29 and 30 reproduce the MMB prophage-mediated defense pattern.
DOI:10.1038/nmicrobiol.2016.251
MMB 29-30 and Phrann 29-30 also confer survival to infection by a lytic Tweety derivative

The PMC author manuscript for Dedrick et al. shows that the MMB gp29-gp30 system can protect bacteria from a lytic Tweety derivative in addition to wild-type Tweety.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
MMB_gp29_gp30 | 10\.1038/nmicrobiol\.2016\.251 | Prophage-mediated defence against viral attack and viral counter-defence

The DefenseFinder model registry maps the named MMB_gp29_gp30 system to the Dedrick et al. prophage-mediated viral-defense paper.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
MMB_gp29_gp30__gp29 | MMB_gp29_gp30__gp29 | MMB_gp29_gp30

The DefenseFinder HMM inventory records an MMB gp29-gp30 profile for MMB_gp29_gp30__gp29 in the MMB_gp29_gp30 model namespace.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
MMB_gp29_gp30__gp30 | MMB_gp29_gp30__gp30 | MMB_gp29_gp30

The DefenseFinder HMM inventory records an MMB gp29-gp30 profile for MMB_gp29_gp30__gp30 in the MMB_gp29_gp30 model namespace.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
MMB_gp29_gp30 MMB_gp29_gp30 2 2 MMB_gp29_gp30__gp29, MMB_gp29_gp30__gp30

The DefenseFinder rules table models MMB_gp29_gp30 as a two-component system requiring gp29 and gp30 profiles.

MMB gp29-gp30 loci confer heterotypic phage defense

Conservative system-level sketch linking possession of an MMB gp29-gp30 locus to restricted bacteriophage propagation without asserting the unresolved lytic trigger, gp29-gp30 interaction, or downstream arrest mechanism.

NONMECHANISTIC · The graph captures MMB gp29-gp30 as a named anti-phage system with DefenseFinder gp29 and gp30 profiles while leaving the direct lytic trigger, MMB gp30 regulatory role, MMB gp29 biochemical activity, and exact downstream arrest mechanism unresolved.

Edge evidence

MMB gp29-gp30 locus contributes to restricted phage propagation RO:0002326
Dedrick et al. show that MMB genes 29 and 30 are necessary and sufficient for the tested MMB defense profile, and DefenseFinder catalogs gp29 and gp30 profiles in the MMB_gp29_gp30 model namespace.
- DOI:10.1038/nmicrobiol.2016.251 we constructed a MMB mutant in which genes 29 and 30 are removed (deletions of individual genes appear to generate non-viable mutants; Supplementary Table 3) and showed that prophage-mediated defense is lost The PMC author manuscript for Dedrick et al. shows that deleting the MMB 29-30 interval abolishes MMB prophage-mediated defense.
- DOI:10.1038/nmicrobiol.2016.251 expressing MMB 29 and 30 confers the same pattern of defense as the MMB lysogen The PMC author manuscript for Dedrick et al. shows that MMB genes 29 and 30 are sufficient to reproduce the MMB defense pattern.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md MMB_gp29_gp30__gp29 | MMB_gp29_gp30__gp29 | MMB_gp29_gp30 The DefenseFinder HMM inventory records an MMB gp29-gp30 profile for MMB_gp29_gp30__gp29 in the MMB_gp29_gp30 model namespace.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md MMB_gp29_gp30__gp30 | MMB_gp29_gp30__gp30 | MMB_gp29_gp30 The DefenseFinder HMM inventory records an MMB gp29-gp30 profile for MMB_gp29_gp30__gp30 in the MMB_gp29_gp30 model namespace.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv MMB_gp29_gp30 MMB_gp29_gp30 2 2 MMB_gp29_gp30__gp29, MMB_gp29_gp30__gp30 The DefenseFinder rules table models MMB_gp29_gp30 as a two-component system requiring gp29 and gp30 profiles.
restricted phage propagation confers MMB gp29-gp30 system METPO:2007700
MMB-gp29-gp30-mediated restriction of phage propagation realizes the MMB gp29-gp30 system trait.
- DOI:10.1038/nmicrobiol.2016.251 expressing MMB 29 and 30 confers the same pattern of defense as the MMB lysogen The PMC author manuscript for Dedrick et al. shows that MMB genes 29 and 30 reproduce the MMB defense pattern.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md MMB_gp29_gp30 | 10\.1038/nmicrobiol\.2016\.251 | Prophage-mediated defence against viral attack and viral counter-defence DefenseFinder records MMB_gp29_gp30 as a named system from the Dedrick et al. prophage-defense paper.
MMB gp29-gp30 system is a phage defense system rdfs:subClassOf
MMB gp29-gp30 system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md | MMB_gp29_gp30 | 10\.1038/nmicrobiol\.2016\.251 | Prophage-mediated defence against viral attack and viral counter-defence | DefenseFinder associates MMB_gp29_gp30 with the Dedrick et al. prophage-mediated viral-defense paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1038/nmicrobiol.2016.251

Parent traits (1)

phage defense system traitmech:000209

Synonyms (1)

MMB_gp29_gp30 RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve the MMB gp29 biochemical activity, MMB gp30 regulatory role, lytic trigger, gp29-gp30 interaction, counter-defense specificity, and homolog breadth before minting narrower MMB gp29-gp30 mechanism children.

KNOWLEDGE GAP OPEN mmb_gp29_gp30-mechanism-gap · raised by codex · 2026-09-20

Attached to causal_graphs#mmb_gp29_gp30_locus_restricts_phage

Dedrick et al. and DefenseFinder support MMB gp29-gp30 as a named anti-phage system with gp29 and gp30 profiles, but the MMB gp29 biochemical activity, direct gp29-gp30 interaction, triggering Tweety early lytic gene or genes, MMB-specific counter-defense tuning, and relationship to Squirty homologs are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-20T00:13:48Z · MINTED_TRAITMECH_ID · codex
Minted MMB gp29-gp30 system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v174.