plasmid carriage

Edge evidence

• plasmid carriage enables conjugation RO:0002327

  Conjugative plasmids encode the machinery for cell-to-cell transfer.

  • DOI:10.1128/MMBR.00020-10 Smillie et al. classify conjugative and mobilizable plasmids.
• plasmid carriage contributes to accessory function RO:0002326

  Plasmids carry accessory genes that extend host phenotype.

  • DOI:10.1038/nrmicro1235 Frost et al. include plasmids among the principal MGEs delivering accessory functions.
• toxin-antitoxin system stabilizes plasmid vertical inheritance

  Toxin-antitoxin systems increase vertical stability of their replicons.

  • DOI:10.1093/nar/gkae018 TA systems are small selfish genetic modules that increase vertical stability of their replicons.
• plasmid-encoded methylase protects against restriction of incoming plasmid DNA

  Plasmid-encoded methylases protect plasmid DNA from host restriction.

  • DOI:10.1093/nar/gkae896 plasmid-encoded methylases that protect plasmids from restriction.
• plasmid-encoded anti-restriction genes protects against restriction of incoming plasmid DNA

  Plasmid-encoded anti-restriction genes counter multiple RM system types.

  • DOI:10.1093/nar/gkae896 plasmid-encoded anti-restriction genes that protect against multiple RM types.
• antibiotic selective pressure promotes retention of plasmid carriage

  Without selection plasmids tend to be lost; antibiotic pressure promotes retention.

  • DOI:10.1080/22221751.2024.2352432 without selection plasmids tend to be lost, whereas antibiotic (or metal) selective pressure promotes retention.
• plasmid carriage imposes plasmid fitness cost

  Plasmid carriage imposes a fitness cost from additional material and energy consumption.

  • DOI:10.1080/22221751.2024.2352432 Plasmid carriage imposes fitness costs (additional material and energy consumption).
• compensatory mutation reduces plasmid fitness cost METPO:2000017

  Compensatory evolution of chromosomes and plasmids counteracts plasmid fitness cost.

  • DOI:10.1002/ece3.70121 Compensatory evolution of chromosomes and plasmids counteracts the plasmid fitness cost.