RosmerTA system

traitmech:000256 · CLASS · PROPOSED

A phage defense system in which an organism possesses a two-component RosmerTA locus represented by RmrA and RmrT profiles that can protect bacteria from bacteriophage infection.

Trait evidence (5)

DOI:10.1016/j.chom.2022.09.017
discovery of 21 defense systems that protect bacteria from phages, based on computational genomic analyses and phage-infection experiments

Millman et al. report the computational and experimental cohort that DefenseFinder cites for RosmerTA as a bacterial anti-phage system.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
RosmerTA | 10\.1016/j\.chom\.2022\.09\.017 | An expanded arsenal of immune systems that protect bacteria from phages

The DefenseFinder model registry maps the named RosmerTA system to the Millman et al. Cell Host & Microbe article; the RosmerTA row in the pinned registry uses the final article DOI and title rather than the bioRxiv preprint DOI used by sibling Millman-system rows.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv
RosmerTA RosmerTA 2 2 RosmerTA__RmrA_2585209417, RosmerTA__RmrT_2585209417

The DefenseFinder rules table models RosmerTA with RmrA and RmrT profiles.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
RosmerTA__RmrA_2585209417 | RosmerTA__RmrA_2585209417 | RosmerTA

The DefenseFinder HMM inventory records RmrA as a RosmerTA profile.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
RosmerTA__RmrT_2585209417 | RosmerTA__RmrT_2585209417 | RosmerTA

The DefenseFinder HMM inventory records RmrT as a RosmerTA profile.

RosmerTA loci confer bacterial phage defense

Conservative system-level sketch linking possession of a RosmerTA locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures RosmerTA as a named anti-phage system with the required DefenseFinder RmrA and RmrT profiles while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved.

Edge evidence

RosmerTA locus contributes to restricted phage propagation RO:0002326
DefenseFinder maps RosmerTA to a bacterial anti-phage-system discovery paper and represents RosmerTA loci through RmrA and RmrT component profiles.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. describe the anti-phage discovery cohort that the DefenseFinder RosmerTA registry row maps to the RosmerTA system.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md RosmerTA | 10\.1016/j\.chom\.2022\.09\.017 | An expanded arsenal of immune systems that protect bacteria from phages The DefenseFinder registry maps RosmerTA itself to the final Millman et al. bacterial antiphage-system paper, unlike sibling rows from the same discovery cohort that still point at the bioRxiv preprint.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/DefenseFinder_rules.tsv RosmerTA RosmerTA 2 2 RosmerTA__RmrA_2585209417, RosmerTA__RmrT_2585209417 The DefenseFinder rules table supports both RmrA and RmrT as required RosmerTA system profiles.
restricted phage propagation confers RosmerTA system METPO:2007700
RosmerTA-mediated phage restriction realizes the RosmerTA system trait.
- DOI:10.1016/j.chom.2022.09.017 discovery of 21 defense systems that protect bacteria from phages Millman et al. place the RosmerTA discovery cohort in the set of bacterial systems that protect against phages.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md RosmerTA | 10\.1016/j\.chom\.2022\.09\.017 | An expanded arsenal of immune systems that protect bacteria from phages DefenseFinder records RosmerTA as a named system from the final Millman et al. antiphage-system paper rather than the bioRxiv preprint used by the neighboring Millman cohort rows.
RosmerTA system is a phage defense system rdfs:subClassOf
RosmerTA system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md An expanded arsenal of immune systems that protect bacteria from phages DefenseFinder associates RosmerTA with the final Cell Host & Microbe version of the Millman et al. bacterial antiphage-system discovery paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.chom.2022.09.017

Parent traits (1)

phage defense system traitmech:000209

Synonyms (1)

RosmerTA EXACT_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve RosmerTA phage triggers and effector outputs before minting narrower RosmerTA mechanism children.

KNOWLEDGE GAP OPEN rosmerta-mechanism-gap · raised by codex · 2026-09-18

Attached to causal_graphs#rosmerta_locus_restricts_phage

Millman et al. and DefenseFinder support RosmerTA as a named anti-phage system with required RmrA and RmrT profiles, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-18T23:49:00Z · MINTED_TRAITMECH_ID · codex
Minted RosmerTA system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v133.