rRNA operon copy number

Edge evidence

• rRNA operon copy number enables ribosome biogenesis RO:0002327

  Higher rrn copy number raises rRNA transcription capacity for ribosome assembly.

  • DOI:10.1128/AEM.66.4.1328-1333.2000 Klappenbach et al. tie rrn copy number to copiotrophic strategies with fast ribosome assembly.
• rRNA operon copy number associated with maximal growth rate biolink:associated_with

  rrn copy number correlates with maximal growth rate across bacteria.

  • DOI:10.1038/nmicrobiol.2016.160 Roller et al. link rrn copy number to bacterial growth rate and growth efficiency.
• rRNA operon copy number increases capacity for rRNA transcription

  Multiple rrn operons increase capacity to raise rRNA transcription and ribosome synthesis rapidly.

  • DOI:10.1128/AEM.66.4.1328-1333.2000 rrn transcription can account for up to ~70% of cellular transcription during rapid growth; multiple operons increase ability to raise ribosome synthesis rapidly.
• rRNA operon copy number decreases growth efficiency RO:0002212

  Higher rrn copy number is associated with lower growth (carbon use) efficiency.

  • DOI:10.1038/nmicrobiol.2016.160 Roller et al.: growth efficiency is inversely related to maximal growth rate and rrn copy number.
• rRNA operon copy number positively associated with chemotactic motility

  Higher rrn copy number is associated with greater probability of chemotactic motility across genomes.

  • DOI:10.1038/nmicrobiol.2016.160 Chemotactic motility shows a positive relationship with log2-rrn (up to +41.25% non-phylogenetic, +10.60% phylogenetic) across 1,167 genomes.
• rRNA operon copy number positively correlates with genome size

  rrn copy number positively correlates with genome size across bacteria.

  • DOI:10.1038/nmicrobiol.2016.160 Genome size and rrn copy number show a positive logarithmic relationship; ~+0.66 Mbp phylogenetically for 15 vs 1 rrn.