6A-MBL system

traitmech:000314 · CLASS · PROPOSED

A phage defense system in which an organism possesses a 6A-MBL locus that can protect bacteria from bacteriophage infection.

Trait evidence (6)

DOI:10.1016/j.chom.2024.07.007
We validated six of these phage defense systems, including factors preventing viral attachment, R-loop-acting enzymes, the inflammasome, ubiquitin pathway, and pathogen recognition signaling.

van den Berg et al. validated six phage defense systems related to eukaryotic innate antiviral responses.
DOI:10.1016/j.chom.2024.07.007
Searching for phage defense systems related to innate antiviral genes from vertebrates and plants, we uncovered over 450 candidates.

van den Berg et al. motivate a conservative system-level record that does not assert a resolved 6A-MBL trigger, effector output, or universal pathway.
https://zenodo.org/records/11209165
In addition, a fused ubiquitin-like E1-E2-JAB protein combined with a putative MBL nuclease (6A-MBL) was found

The Zenodo manuscript/supplementary-data record from van den Berg et al. names 6A-MBL as a putative MBL-nuclease system candidate.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
6A_MBL | 10\.1016/j\.chom\.2024\.07\.007 | Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses

The DefenseFinder article registry maps the named 6A-MBL system to the van den Berg et al. antiphage-system discovery paper.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
6A_MBL__cap2_3 | | 6A_MBL

The DefenseFinder HMM inventory records 6A_MBL__cap2_3 as a cap2_3 profile in the 6A_MBL model namespace.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
6A_MBL__MblB | | 6A_MBL

The DefenseFinder HMM inventory records 6A_MBL__MblB as a MblB profile in the 6A_MBL model namespace.

6A-MBL loci confer bacterial phage defense

Conservative system-level sketch linking possession of a 6A-MBL locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures 6A-MBL as a named anti-phage system with 6A_MBL__cap2_3 and 6A_MBL__MblB DefenseFinder HMM profile entries while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved.

Edge evidence

6A-MBL locus contributes to restricted phage propagation RO:0002326
DefenseFinder maps 6A_MBL to a eukaryotic-antiviral-homolog antiphage-system discovery paper and catalogs cap2_3 and MblB HMM profile entries in the 6A_MBL model namespace.
- DOI:10.1016/j.chom.2024.07.007 We validated six of these phage defense systems, including factors preventing viral attachment, R-loop-acting enzymes, the inflammasome, ubiquitin pathway, and pathogen recognition signaling. van den Berg et al. validated six phage defense systems related to eukaryotic innate antiviral responses.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md 6A_MBL | 10\.1016/j\.chom\.2024\.07\.007 | Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses The DefenseFinder article registry maps the named 6A-MBL system to the van den Berg et al. antiphage-system discovery paper.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md 6A_MBL__cap2_3 | | 6A_MBL The DefenseFinder HMM inventory records 6A_MBL__cap2_3 as a cap2_3 profile in the 6A_MBL model namespace.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md 6A_MBL__MblB | | 6A_MBL The DefenseFinder HMM inventory records 6A_MBL__MblB as a MblB profile in the 6A_MBL model namespace.
restricted phage propagation confers 6A-MBL system METPO:2007700
6A-MBL-mediated phage restriction realizes the 6A-MBL system trait.
- DOI:10.1016/j.chom.2024.07.007 We validated six of these phage defense systems, including factors preventing viral attachment, R-loop-acting enzymes, the inflammasome, ubiquitin pathway, and pathogen recognition signaling. van den Berg et al. validated six phage defense systems related to eukaryotic innate antiviral responses.
6A-MBL system is a phage defense system rdfs:subClassOf
6A-MBL system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md 6A_MBL | 10\.1016/j\.chom\.2024\.07\.007 | Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses The DefenseFinder article registry maps the named 6A-MBL system to the van den Berg et al. antiphage-system discovery paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1016/j.chom.2024.07.007

Parent traits (1)

phage defense system traitmech:000209

Synonyms (4)

6A-MBL EXACT_SYNONYM · https://zenodo.org/records/11209165
6A_MBL RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
cap2_3 RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
MblB RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve 6A-MBL phage triggers and effector outputs before minting narrower 6A-MBL mechanism children.

KNOWLEDGE GAP OPEN six-a-mbl-mechanism-gap · raised by codex · 2026-09-20

Attached to causal_graphs#six_a_mbl_locus_restricts_phage

van den Berg et al. and DefenseFinder support 6A-MBL as a named anti-phage system with 6A_MBL__cap2_3 and 6A_MBL__MblB HMM profile entries, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-20T16:42:08Z · MINTED_TRAITMECH_ID · codex
Minted 6A-MBL system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, history, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v191.
2026-09-20T16:43:08Z · REVIEW_CANONICAL_EXAMPLE_EVIDENCE_GAP · codex
Reviewed the 6A-MBL canonical_examples gap and left canonical_examples empty: the current evidence supports a named phage-defense system and DefenseFinder profiles, but the curated record does not yet cite a source-backed bacterial taxon with a directly observed 6A-MBL locus. No paid research was used.
2026-09-20T17:16:31Z · CURATION_REVIEW_REVISION · codex
Resolved issue #1148 by sourcing the exact 6A-MBL synonym from the stable van den Berg Zenodo record that names 6A-MBL verbatim, leaving DefenseFinder model and component labels as related synonyms.