Toutatis system

traitmech:000267 · CLASS · PROPOSED

A phage defense system in which an organism possesses a Toutatis locus represented by TutA_VCA0446 and TutB_VCA0447 profiles that can protect bacteria from bacteriophage infection.

Trait evidence (5)

DOI:10.1126/science.ads0768
nearly 10% of the integron cassettes in the pandemic Vibrio cholerae strain encode novel antiphage functions

Darracq et al. support treating the newly discovered Vibrio cholerae SCI antiphage cassettes as bacterial anti-phage systems.
DOI:10.1126/science.ads0768
Most of these novel systems have little or no similarity to previously known ones, with several providing defense through cell lysis or growth arrest

Darracq et al. support a conservative system record that does not assert a resolved Toutatis trigger, effector output, or universal pathway.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
Toutatis | 10\.1126/science\.ads0768 | Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems

The DefenseFinder model registry maps the named Toutatis system to the Darracq et al. SCI antiphage-system paper.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Toutatis__TutA_VCA0446 | | Toutatis

The DefenseFinder HMM inventory records TutA_VCA0446 in the Toutatis model namespace.
https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
Toutatis__TutB_VCA0447 | | Toutatis

The DefenseFinder HMM inventory records TutB_VCA0447 in the Toutatis model namespace.

Toutatis loci confer bacterial phage defense

Conservative system-level sketch linking possession of a Toutatis locus to restricted bacteriophage propagation without asserting the unresolved phage trigger or molecular output.

NONMECHANISTIC · The graph captures Toutatis as a named SCI-derived anti-phage system with TutA_VCA0446 and TutB_VCA0447 DefenseFinder profiles while leaving its phage trigger, molecular substrate, antiviral effector output, and subtype breadth unresolved.

Edge evidence

Toutatis locus contributes to restricted phage propagation RO:0002326
DefenseFinder maps Toutatis to an SCI anti-phage-system discovery paper and represents Toutatis loci through the TutA_VCA0446 and TutB_VCA0447 component profiles.
- DOI:10.1126/science.ads0768 nearly 10% of the integron cassettes in the pandemic Vibrio cholerae strain encode novel antiphage functions Darracq et al. describe the newly discovered antiphage-system cohort that the DefenseFinder Toutatis registry row maps to the Toutatis system.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md Toutatis__TutA_VCA0446 | | Toutatis The DefenseFinder HMM inventory supports TutA_VCA0446 as one Toutatis component profile.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md Toutatis__TutB_VCA0447 | | Toutatis The DefenseFinder HMM inventory supports TutB_VCA0447 as one Toutatis component profile.
restricted phage propagation confers Toutatis system METPO:2007700
Toutatis-mediated phage restriction realizes the Toutatis system trait.
- DOI:10.1126/science.ads0768 Most of these novel systems have little or no similarity to previously known ones Darracq et al. place the Toutatis discovery cohort in a set of novel bacterial systems that protect against phages.
Toutatis system is a phage defense system rdfs:subClassOf
Toutatis system possession is a phage-defense-system trait.
- https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md Toutatis | 10\.1126/science\.ads0768 | Sedentary chromosomal integrons as biobanks of bacterial antiphage defense systems DefenseFinder associates Toutatis with the Darracq et al. bacterial antiphage-system paper.

Provenance

Identifier source: TraitMech local identifier
Definition source: DOI:10.1126/science.ads0768

Parent traits (1)

phage defense system traitmech:000209

Synonyms (3)

Toutatis EXACT_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/List_system_article.md
TutA_VCA0446 RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md
TutB_VCA0447 RELATED_SYNONYM · https://raw.githubusercontent.com/mdmparis/defense-finder-models/afb0e5a8b466be53586b13266f5d38d98c3ac268/Liste_hmm_system.md

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Discussions and Knowledge Gaps (1)

Open questions attached to this trait. Seeded by just knowledge-gap-scan and curated; see the corpus-wide index.

Resolve Toutatis phage triggers and effector outputs before minting narrower Toutatis mechanism children.

KNOWLEDGE GAP OPEN toutatis-mechanism-gap · raised by codex · 2026-09-19

Attached to causal_graphs#toutatis_locus_restricts_phage

Darracq et al. and DefenseFinder support Toutatis as a named anti-phage system with TutA_VCA0446 and TutB_VCA0447 profiles, but the trigger, molecular substrate, antiviral effector output, and subtype-specific mechanism are not resolved enough here to assert a narrower mechanistic child trait.

Curation history

2026-09-19T06:05:05Z · MINTED_TRAITMECH_ID · codex
Minted Toutatis system as a DOI-backed GENOMICS TraitRecord under phage defense system after an ignored-and-hidden duplicate review found no exact live TraitMech, METPO, or prior proposal record; the replacement placeholder is reserved in proposals/metpo_traitmech_v144.