clathrin-coated endocytic vesicle lumen

GO:0106176 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by the membrane of a clathrin-coated endocytic vesicle. [GO:0106176]

Part of: clathrin-coated endocytic vesicle (GO:0045334)

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast forms clathrin-dependent endocytic vesicles at cortical actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast endocytic-site model in which clathrin and adaptor protein dynamics mark clathrin-coated vesicle formation. [DOI:10.1016/j.devcel.2005.04.014]

The clathrin-coated endocytic vesicle membrane bounds the clathrin-coated endocytic vesicle lumen inside the endocytic coated vesicle.

Subject	Predicate	Object	Evidence
clathrin-coated endocytic vesicle lumen	is part of	clathrin-coated endocytic vesicle	`GO:0106176` GO:0106176 defines this lumen as the volume enclosed by a clathrin-coated endocytic vesicle membrane. `GO:0045334` GO:0045334 identifies the enclosing clathrin-coated endocytic vesicle.
clathrin-coated endocytic vesicle membrane	bounds	clathrin-coated endocytic vesicle lumen	`GO:0106176` GO:0106176 defines the lumen by enclosure within the vesicle membrane. `GO:0030669` GO:0030669 identifies the surrounding clathrin-coated endocytic vesicle membrane.

INTERPRETATION (RESOLVED): Link GO:0106176 under the generic clathrin-coated vesicle lumen as well as the GO endocytic vesicle lumen. GO:0106176 names the lumen inside the clathrin-coated endocytic vesicle, GO:0045334 is a subtype of GO:0030136 clathrin-coated vesicle, and this corpus already has a generic cellstructuremech:clathrin_coated_vesicle_lumen parent for lumen records in clathrin-coated vesicles.
INTERPRETATION (RESOLVED): Keep internalized cargo out of the clathrin-coated endocytic vesicle lumen record. GO:0106176 denotes the bounded lumen rather than a stable cargo cohort, and clathrin-coated endocytic vesicles carry cargo that varies by endocytic event.

GO:0106176 Gene Ontology cellular-component term for the clathrin-coated endocytic vesicle lumen.
GO:0071682 Gene Ontology cellular-component parent term for endocytic vesicle lumens.
GO:0045334 Gene Ontology cellular-component term for the whole clathrin-coated endocytic vesicle.
GO:0030136 Gene Ontology cellular-component term for the broader clathrin-coated vesicle class.
GO:0030669 Gene Ontology cellular-component term for the clathrin-coated endocytic vesicle membrane that bounds the lumen.
DOI:10.1016/j.devcel.2005.04.014 Newpher et al. 2005, In Vivo Dynamics of Clathrin and Its Adaptor-Dependent Recruitment to the Actin-Based Endocytic Machinery in Yeast, Developmental Cell.

2026-09-16T09:20:58Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-16T09:21:38Z codex · EXPANDED_RECORD — Added GO endocytic-vesicle-lumen parentage, whole-vesicle parthood, Saccharomyces endocytic-site scope, GO/DOI evidence, a nonmechanistic lumen topology graph, and a resolved cargo-boundary discussion.
2026-09-16T09:33:26Z codex · ADDRESSED_PR_REVIEW — Resolved issue #1083 by adding the local generic clathrin-coated-vesicle lumen parentage and supporting GO:0030136 evidence.