clathrin-coated endocytic vesicle

GO:0045334 · Membrane organelle · Membrane bounded organelle · Proposed

A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. [GO:0045334]

Has part: clathrin coat of endocytic vesicle (GO:0030128); clathrin-coated endocytic vesicle membrane (GO:0030669)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has clathrin and adaptor proteins that are recruited to cortical actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which clathrin and adaptor protein dynamics defined the timing of clathrin coat assembly at cortical actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

Functions

clathrin-dependent endocytosis GO:0072583 — Clathrin-coated endocytic vesicles form during clathrin-dependent endocytosis.
- GO:0072583 GO:0072583 denotes endocytosis through clathrin-coated pits that form clathrin-coated endocytic vesicles.
- DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005 analyzed the modular clathrin- and actin-mediated endocytic machinery in yeast.

Mechanism graphs

Clathrin-coated endocytic vesicle topology (FUNCTION)

The clathrin-coated endocytic vesicle membrane and its endocytic clathrin coat are parts of the clathrin-coated endocytic vesicle formed during clathrin-dependent endocytosis.

Subject	Predicate	Object	Evidence
clathrin coat of endocytic vesicle	is part of	clathrin-coated endocytic vesicle membrane	`GO:0030128` GO:0030128 records the endocytic vesicle clathrin coat as part of GO:0030669.
clathrin coat of endocytic vesicle	is part of	clathrin-coated endocytic vesicle	`GO:0045334` GO:0045334 identifies the clathrin-coated, membrane-bounded endocytic vesicle. `GO:0030128` GO:0030128 identifies the clathrin coat found on an endocytic vesicle.
clathrin-coated endocytic vesicle membrane	is part of	clathrin-coated endocytic vesicle	`GO:0030669` GO:0030669 identifies the membrane as part of GO:0045334.
clathrin-coated endocytic vesicle membrane	bounds	clathrin-coated endocytic vesicle	`GO:0030669` GO:0030669 records a bounding-layer relationship to GO:0045334. `GO:0045334` GO:0045334 identifies the bounded clathrin-coated endocytic vesicle.
clathrin-coated endocytic vesicle	participates in	clathrin-dependent endocytosis	`GO:0072583` GO:0072583 describes clathrin-dependent endocytosis via clathrin-coated pits that form clathrin-coated endocytic vesicles. `DOI:10.1016/j.cell.2005.09.024` Kaksonen, Toret and Drubin 2005 analyzed the yeast clathrin- and actin-mediated endocytic machinery.

Discussions

INTERPRETATION (RESOLVED): Keep clathrin chains and endocytic adaptor proteins on the clathrin coat of endocytic vesicle record. The whole-vesicle record uses GO:0030128 and GO:0030669 for its named coat and membrane substructures, and those records carry lower-level protein and lipid constituents.

Evidence

GO:0045334 Gene Ontology cellular-component term for the whole clathrin-coated endocytic vesicle.
GO:0030136 Gene Ontology cellular-component parent term for clathrin-coated vesicles.
GO:0030139 Gene Ontology cellular-component parent term for endocytic vesicles.
GO:0030669 Gene Ontology cellular-component term for the membrane bounding a clathrin-coated endocytic vesicle.
GO:0030128 Gene Ontology cellular-component term for the clathrin coat of an endocytic vesicle.
GO:0072583 Gene Ontology biological-process term for clathrin-dependent endocytosis.
DOI:10.1016/j.devcel.2005.04.014 Newpher et al. 2005, In Vivo Dynamics of Clathrin and Its Adaptor-Dependent Recruitment to the Actin-Based Endocytic Machinery in Yeast, Developmental Cell.
DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005, A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery, Cell.

Curation history

2026-09-16T08:48:12Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-16T08:48:52Z codex · EXPANDED_RECORD — Added GO parentage, endocytic clathrin coat and membrane parts, Saccharomyces endocytic-site scope, a clathrin-dependent endocytosis function, GO/DOI evidence, a nonmechanistic endocytic vesicle topology graph, and a whole-vesicle component-boundary discussion.
2026-09-16T09:00:55Z codex · ADDRESSED_PR_REVIEW — Resolved issue #1081 by adding a direct endocytic clathrin coat to whole clathrin-coated endocytic vesicle edge to the topology graph.

Source: data/structures/membrane_organelle/clathrin_coated_endocytic_vesicle.yaml