clathrin-coated endocytic vesicle membrane

GO:0030669 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding a clathrin-coated endocytic vesicle. [GO:0030669]

Part of: clathrin-coated endocytic vesicle (GO:0045334)

Has part: clathrin coat of endocytic vesicle (GO:0030128)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
clathrin-coated endocytic vesicle membrane lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Lipid-bilayer constituent of the clathrin-coated endocytic vesicle membrane that surrounds a clathrin-coated endocytic vesicle. `GO:0030669` GO:0030669 identifies the membrane surrounding a clathrin-coated endocytic vesicle.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has clathrin and adaptor proteins that are recruited to cortical actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which clathrin and adaptor protein dynamics defined the timing of clathrin coat assembly at cortical actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

Mechanism graphs

Clathrin-coated endocytic vesicle membrane topology (FUNCTION)

The clathrin-coated endocytic vesicle membrane is the lipid-bilayer boundary of a clathrin-coated endocytic vesicle carrying an endocytic clathrin coat.

Subject	Predicate	Object	Evidence
clathrin coat of endocytic vesicle	is part of	clathrin-coated endocytic vesicle membrane	`GO:0030128` GO:0030128 is directly part of GO:0030669.
clathrin-coated endocytic vesicle membrane	is part of	clathrin-coated endocytic vesicle	`GO:0030669` GO:0030669 identifies the membrane as part of GO:0045334.
clathrin-coated endocytic vesicle membrane	bounds	clathrin-coated endocytic vesicle	`GO:0030669` GO:0030669 records a bounding-layer relationship to GO:0045334. `GO:0045334` GO:0045334 identifies the bounded clathrin-coated endocytic vesicle.
clathrin-coated endocytic vesicle	participates in	clathrin-dependent endocytosis	`GO:0072583` GO:0072583 describes clathrin-dependent endocytosis via clathrin-coated pits that form clathrin-coated endocytic vesicles. `DOI:10.1016/j.cell.2005.09.024` Kaksonen, Toret and Drubin 2005 analyzed the yeast clathrin- and actin-mediated endocytic machinery.

Discussions

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the clathrin-coated endocytic vesicle membrane. GO:0030669 exactly grounds the clathrin-coated endocytic vesicle membrane, but the membrane lipid-bilayer constituent is intentionally left as reviewed-label-only until an exact source-neutral lipid or membrane-constituent CURIE is curated.
INTERPRETATION (RESOLVED): Keep the endocytic clathrin coat as a vesicle membrane part rather than a lipid-bilayer membrane component. GO:0030128 denotes the clathrin protein coat on the endocytic vesicle, whereas GO:0030669 denotes the lipid bilayer surrounding that vesicle.

Evidence

GO:0030669 Gene Ontology cellular-component term for the clathrin-coated endocytic vesicle membrane.
GO:0030665 Gene Ontology cellular-component parent term for clathrin-coated vesicle membranes.
GO:0030666 Gene Ontology cellular-component parent term for endocytic vesicle membranes.
GO:0045334 Gene Ontology cellular-component term for the whole clathrin-coated endocytic vesicle bounded by GO:0030669.
GO:0030128 Gene Ontology cellular-component term for the clathrin coat part of GO:0030669.
GO:0072583 Gene Ontology biological-process term for clathrin-dependent endocytosis.
DOI:10.1016/j.devcel.2005.04.014 Newpher et al. 2005, In Vivo Dynamics of Clathrin and Its Adaptor-Dependent Recruitment to the Actin-Based Endocytic Machinery in Yeast, Developmental Cell.
DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005, A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery, Cell.

Curation history

2026-09-16T08:18:28Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-16T08:19:31Z codex · EXPANDED_RECORD — Added GO parentage, clathrin-coated endocytic vesicle parthood, a reviewed-label-only lipid-bilayer component, Saccharomyces endocytic-site scope, GO/DOI evidence, a nonmechanistic endocytic vesicle membrane topology graph, and lipid-grounding plus clathrin-coat boundary discussions.
2026-09-16T08:30:13Z codex · ADDRESSED_PR_REVIEW — Resolved PR #1078 review issue #1079 by adding the endocytic clathrin coat to record-level has_part.

Source: data/structures/membrane_organelle/clathrin_coated_endocytic_vesicle_membrane.yaml