clathrin coat of endocytic vesicle

GO:0030128 · Other · Multiprotein complex · Proposed

A clathrin coat found on an endocytic vesicle. [GO:0030128]

Synonyms: clathrin coat of endocytotic vesicle

Part of: clathrin-coated endocytic vesicle membrane (GO:0030669)

Has part: AP-2 adaptor complex (GO:0030122)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
clathrin triskelion scaffold	Protein complex	part of	Reviewed label only (reviewed name; no accession asserted)			UNKNOWN	Core clathrin triskelion lattice that polymerizes into the coat on an endocytic vesicle. `GO:0030128` GO:0030128 defines this structure as a clathrin coat on an endocytic vesicle. `GO:0030118` GO:0030118 defines clathrin coats as polymerized clathrin triskelions linked to membranes by adaptor complexes.
endocytic clathrin adaptor and cargo-selection factors	Protein	part of	Reviewed label only (reviewed name; no accession asserted)			UNKNOWN	Adaptor and cargo-selection factors that connect endocytic clathrin coat assembly to vesicle membranes and cargo sorting. `GO:0030118` GO:0030118 frames clathrin coats as linked to membranes through adaptor complexes. `GO:0030119` GO:0030119 identifies AP-type membrane coat adaptor complexes as membrane-coat components that link clathrin or another coat-forming molecule to a membrane surface. `DOI:10.1016/j.devcel.2005.04.014` Newpher et al. 2005 measured clathrin and adaptor dynamics at budding-yeast cortical actin-based endocytic sites.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has clathrin and adaptor proteins that are recruited to cortical actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which fluorescently tagged clathrin and adaptor proteins established the timing of clathrin recruitment to cortical actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

Functions

clathrin-dependent endocytosis GO:0072583 — The clathrin coat of endocytic vesicles participates in clathrin-dependent endocytosis by organizing coated endocytic vesicles.
- GO:0072583 GO:0072583 denotes endocytic uptake through clathrin-coated pits that form clathrin-coated endocytic vesicles.
- DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005 analyzed the modular clathrin- and actin-mediated endocytic machinery in yeast.

Mechanism graphs

Endocytic clathrin coat is carried by an endocytic vesicle membrane (FUNCTION)

The clathrin coat of an endocytic vesicle is a clathrin/adaptor protein coat on a clathrin-coated endocytic vesicle membrane.

Subject	Predicate	Object	Evidence
clathrin triskelion scaffold	polymerizes into	clathrin coat of endocytic vesicle	`GO:0030118` GO:0030118 defines clathrin coats as polymerized clathrin triskelions. `GO:0030128` GO:0030128 identifies the endocytic vesicle-specific clathrin coat.
AP-2 adaptor complex	is part of	clathrin coat of endocytic vesicle	`GO:0030122` GO:0030122 is directly part of GO:0030128.
endocytic clathrin adaptor and cargo-selection factors	links scaffold to	clathrin-coated endocytic vesicle membrane	`GO:0030119` GO:0030119 defines AP-type adaptors as linking clathrin or another coat-forming molecule to a membrane surface. `DOI:10.1016/j.devcel.2005.04.014` Newpher et al. 2005 measured adaptor-dependent clathrin recruitment to the yeast actin-based endocytic machinery.
endocytic clathrin adaptor and cargo-selection factors	is part of	clathrin coat of endocytic vesicle	`GO:0030118` GO:0030118 defines clathrin coats as clathrin triskelions linked to membranes through adaptor complexes. `DOI:10.1016/j.devcel.2005.04.014` Newpher et al. 2005 studied clathrin and adaptor recruitment at yeast endocytic sites.
clathrin coat of endocytic vesicle	is part of	clathrin-coated endocytic vesicle membrane	`GO:0030128` GO:0030128 records the endocytic vesicle clathrin coat as part of GO:0030669.
clathrin-coated endocytic vesicle membrane	is part of	clathrin-coated endocytic vesicle	`GO:0030669` GO:0030669 identifies the clathrin-coated endocytic vesicle membrane. `GO:0045334` GO:0045334 identifies the containing clathrin-coated endocytic vesicle.
clathrin coat of endocytic vesicle	participates in	clathrin-dependent endocytosis	`GO:0072583` GO:0072583 describes endocytosis via clathrin-coated pits that form clathrin-coated endocytic vesicles. `DOI:10.1016/j.cell.2005.09.024` Kaksonen, Toret and Drubin 2005 analyzed the yeast clathrin- and actin-mediated endocytic machinery.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral groundings for endocytic-vesicle clathrin triskelions and adaptor or cargo-selection factors. GO:0030128 exactly grounds the endocytic-vesicle clathrin coat and GO:0030122 captures its exact AP-2 adaptor-complex part, but this initial pass keeps the clathrin triskelion scaffold and broader non-AP-2 endocytic adaptor classes reviewed-label-only until exact source-neutral complex or protein-family identifiers are curated.
INTERPRETATION (RESOLVED): Keep the endocytic-vesicle clathrin coat distinct from the broader clathrin vesicle coat record. GO:0030128 is the clathrin coat subtype on endocytic vesicles, while GO:0030125 is the broader clathrin vesicle coat parent that also covers TGN and synaptic vesicle subtypes.

Evidence

GO:0030128 Gene Ontology cellular-component term for the clathrin coat of an endocytic vesicle.
GO:0030125 Gene Ontology cellular-component parent term for clathrin vesicle coats.
GO:0030669 Gene Ontology cellular-component term for the clathrin-coated endocytic vesicle membrane that carries GO:0030128 as a part.
GO:0045334 Gene Ontology cellular-component term for the whole clathrin-coated endocytic vesicle.
GO:0030122 Gene Ontology cellular-component term for the AP-2 adaptor complex part of GO:0030128.
GO:0030118 Gene Ontology cellular-component term for clathrin coats.
GO:0030119 Gene Ontology cellular-component term for AP-type membrane coat adaptor complexes.
GO:0072583 Gene Ontology biological-process term for clathrin-dependent endocytosis.
DOI:10.1016/j.devcel.2005.04.014 Newpher et al. 2005, In Vivo Dynamics of Clathrin and Its Adaptor-Dependent Recruitment to the Actin-Based Endocytic Machinery in Yeast, Developmental Cell.
DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005, A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery, Cell.

Curation history

2026-09-16T07:49:12Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-16T07:50:50Z codex · EXPANDED_RECORD — Added clathrin-vesicle-coat parentage, endocytic vesicle membrane parthood, AP-2 has-part topology, the GO exact synonym, reviewed-label-only triskelion and adaptor components, Saccharomyces endocytic-site scope, GO/DOI evidence, a nonmechanistic endocytic clathrin-coat topology graph, and grounding plus subtype-boundary discussions.
2026-09-16T08:01:45Z codex · ADDRESSED_PR_REVIEW — Resolved PR #1076 review issue #1077 by narrowing the coarse endocytic adaptor component wording around the exact AP-2 has-part assertion.

Source: data/structures/other/clathrin_coat_of_endocytic_vesicle.yaml