clathrin-coated vesicle membrane

GO:0030665 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding a clathrin-coated vesicle. [GO:0030665]

Synonyms: Clathrin-coated vesicular membrane

Part of: clathrin-coated vesicle (GO:0030136)

Xrefs: uniprot.location:SL-0071 — Clathrin-coated vesicle membrane

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
clathrin-coated vesicle membrane lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Lipid-bilayer constituent of the clathrin-coated vesicle membrane that surrounds a clathrin-coated vesicle. `GO:0030665` GO:0030665 identifies the membrane surrounding a clathrin-coated vesicle. `uniprot.location:SL-0071` — Clathrin-coated vesicle membrane UniProt Subcellular Location SL-0071 maps to GO:0030665 and denotes the clathrin-coated vesicle membrane.

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has clathrin heavy and light chains that assemble at cortical clathrin-dependent endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which clathrin and adaptor protein dynamics defined the timing of coat assembly at actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

The clathrin-coated vesicle membrane is the lipid-bilayer boundary of a clathrin-coated vesicle.

Subject	Predicate	Object	Evidence
clathrin-coated vesicle membrane	is part of	clathrin-coated vesicle	`GO:0030665` GO:0030665 identifies the clathrin-coated vesicle membrane. `GO:0030136` GO:0030136 identifies the containing clathrin-coated vesicle.
clathrin-coated vesicle membrane	bounds	clathrin-coated vesicle	`GO:0030665` GO:0030665 identifies the membrane surrounding a clathrin-coated vesicle. `uniprot.location:SL-0071` — Clathrin-coated vesicle membrane UniProt SL-0071 denotes the clathrin-coated vesicle membrane.

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the clathrin-coated vesicle membrane. The record is exactly grounded to GO:0030665, but the clathrin-coated vesicle membrane lipid-bilayer constituent is intentionally left as reviewed-label-only until an exact source-neutral lipid or membrane-constituent CURIE is curated.
INTERPRETATION (RESOLVED): Keep the clathrin vesicle coat as a whole-vesicle part rather than as a lipid-bilayer membrane component. GO:0030125 denotes the clathrin protein coat on the whole coated vesicle, whereas GO:0030665 denotes the membrane surrounding that vesicle.

GO:0030665 Gene Ontology cellular-component term for the clathrin-coated vesicle membrane.
GO:0030659 Gene Ontology cellular-component term for cytoplasmic vesicle membranes.
GO:0030662 Gene Ontology cellular-component parent term for coated vesicle membranes.
GO:0030136 Gene Ontology cellular-component term for the containing clathrin-coated vesicle.
GO:0030125 Gene Ontology cellular-component term for the clathrin vesicle coat.
uniprot.location:SL-0071 — Clathrin-coated vesicle membrane UniProt Subcellular Location entry SL-0071 maps to GO:0030665 and lists Clathrin-coated vesicular membrane as a synonym.
DOI:10.1016/j.devcel.2005.04.014 Newpher et al. 2005, In Vivo Dynamics of Clathrin and Its Adaptor-Dependent Recruitment to the Actin-Based Endocytic Machinery in Yeast, Developmental Cell.

2026-09-14T19:47:08Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-14T19:48:23Z codex · EXPANDED_RECORD — Added GO vesicle-membrane and coated-vesicle membrane parentage, clathrin-coated-vesicle parthood, the UniProt SL xref and synonym, a reviewed-label-only lipid-bilayer component, Saccharomyces scope, GO/DOI evidence, a nonmechanistic vesicle-membrane topology graph, and lipid-grounding plus clathrin-coat boundary discussions.
2026-09-14T19:57:45Z codex · REVIEW_FIX — Addressed issue #892 by tightening the GO:0030665 definition to state that the clathrin-coated vesicle membrane is a lipid bilayer.