clathrin-coated vesicle

GO:0030136 · Membrane organelle · Membrane bounded organelle · Proposed

A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes. [GO:0030136]

Synonyms: CCV

Has part: clathrin vesicle coat (GO:0030125); clathrin-coated vesicle membrane (GO:0030665)

Xrefs: uniprot.location:SL-0070 — Clathrin-coated vesicle

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has clathrin heavy and light chains that assemble at cortical clathrin-dependent endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which clathrin and adaptor protein dynamics defined the timing of coat assembly at actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

clathrin-dependent endocytosis GO:0072583 — Clathrin-coated vesicles are coated carriers formed during clathrin-dependent endocytic uptake.
- GO:0072583 GO:0072583 denotes endocytosis through clathrin-coated pits and clathrin-coated endocytic vesicles.
- DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005 analyzed the modular clathrin- and actin-mediated endocytic machinery in yeast.

The clathrin vesicle coat and clathrin-coated vesicle membrane are parts of clathrin-coated vesicles formed during clathrin-dependent endocytosis.

Subject	Predicate	Object	Evidence
clathrin vesicle coat	is part of	clathrin-coated vesicle	`GO:0030136` GO:0030136 defines clathrin-coated vesicles by a coat formed of clathrin.
clathrin-coated vesicle membrane	is part of	clathrin-coated vesicle	`GO:0030665` GO:0030665 identifies the clathrin-coated vesicle membrane.
clathrin-coated vesicle	participates in	clathrin-dependent endocytosis	`GO:0072583` GO:0072583 describes clathrin-dependent endocytosis as a form of endocytic uptake through clathrin-coated pits and vesicles. `DOI:10.1016/j.cell.2005.09.024` Kaksonen, Toret and Drubin 2005 analyzed the modular yeast clathrin- and actin-mediated endocytic machinery.

INTERPRETATION (RESOLVED): Keep clathrin heavy and light chains and clathrin adaptors on the clathrin vesicle coat record rather than duplicating them as direct clathrin-coated vesicle components. The whole-vesicle record uses GO:0030125 for its clathrin coat part, and the coat record already models clathrin heavy and light chains as clathrin coat constituents while leaving adaptor-module boundaries open.

GO:0030136 Gene Ontology cellular-component term for clathrin-coated vesicles.
GO:0030135 Gene Ontology cellular-component parent term for coated vesicles.
GO:0030125 Gene Ontology cellular-component term for the clathrin vesicle coat that is part of clathrin-coated vesicles.
GO:0030665 Gene Ontology cellular-component term for the clathrin-coated vesicle membrane.
uniprot.location:SL-0070 — Clathrin-coated vesicle UniProt Subcellular Location entry SL-0070 maps to GO:0030136 and lists CCV as a synonym of clathrin-coated vesicle.
GO:0072583 Gene Ontology biological-process term for clathrin-dependent endocytosis.
DOI:10.1016/j.devcel.2005.04.014 Newpher et al. 2005, In Vivo Dynamics of Clathrin and Its Adaptor-Dependent Recruitment to the Actin-Based Endocytic Machinery in Yeast, Developmental Cell.
DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005, A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery, Cell.

2026-09-14T19:17:21Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-14T19:18:02Z codex · EXPANDED_RECORD — Added coated-vesicle parentage, clathrin coat and clathrin-coated vesicle membrane parts, Saccharomyces scope, a clathrin-dependent endocytosis function, GO/DOI evidence, a nonmechanistic clathrin-coated vesicle topology graph, and a resolved coat-component boundary discussion.
2026-09-14T19:30:49Z codex · REVIEW_FIX — Addressed issue #890 by adding the UniProt SL-0070 xref, the CCV exact synonym, and supporting UniProt Subcellular Location evidence.