clathrin vesicle coat

GO:0030125 · Other · Multiprotein complex · Proposed

A membrane vesicle coat whose core lattice is built from clathrin and that coats clathrin-coated vesicles. [GO:0030125]

Part of: clathrin-coated vesicle (GO:0030136)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
clathrin heavy chain	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	CHC1		UNKNOWN	Core clathrin subunit in yeast clathrin vesicle coats and clathrin-dependent endocytic sites. `DOI:10.1083/jcb.106.5.1453` Payne et al. 1988 analyzed Saccharomyces cerevisiae cells deficient in clathrin heavy chain. `DOI:10.1016/j.devcel.2005.04.014` Newpher et al. 2005 imaged clathrin dynamics and adaptor-dependent recruitment to the yeast actin-based endocytic machinery.
clathrin light chain	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	CLC1		UNKNOWN	Clathrin light-chain subunit that supports yeast clathrin function and endocytic vesicle formation. `DOI:10.1074/jbc.271.51.33123` Chu, Pishvaee and Payne 1996 showed that the clathrin light chain subunit is required for clathrin function in Saccharomyces cerevisiae. `DOI:10.1016/j.devcel.2005.04.014` Newpher et al. 2005 followed adaptor-dependent yeast clathrin recruitment at endocytic sites.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has clathrin heavy and light chains that act at cortical clathrin-dependent endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which fluorescently tagged clathrin and adaptor proteins established the timing of clathrin recruitment to actin-based endocytic sites. [DOI:10.1016/j.devcel.2005.04.014]

Functions

clathrin-dependent endocytosis GO:0072583 — The clathrin vesicle coat participates in clathrin-dependent endocytic uptake by organizing coated endocytic vesicles.
- GO:0072583 GO:0072583 denotes endocytosis through clathrin-coated pits and clathrin-coated endocytic vesicles.
- DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005 analyzed the modular clathrin- and actin-mediated endocytic machinery in yeast.

Mechanism graphs

Clathrin assembles at yeast endocytic sites (ASSEMBLY)

In Saccharomyces cerevisiae, clathrin heavy and light chains join early cortical endocytic sites and form clathrin coats that participate in clathrin-dependent endocytosis.

Subject	Predicate	Object	Evidence
clathrin heavy chain	is part of	clathrin vesicle coat	`DOI:10.1083/jcb.106.5.1453` Payne et al. 1988 analyzed yeast clathrin heavy chain mutants.
clathrin light chain	is part of	clathrin vesicle coat	`DOI:10.1074/jbc.271.51.33123` Chu, Pishvaee and Payne 1996 established yeast clathrin light-chain function.
clathrin vesicle coat	assembles at	cortical endocytic site	`DOI:10.1016/j.devcel.2005.04.014` Newpher et al. 2005 measured the timing of clathrin recruitment to the yeast actin-based endocytic machinery.
clathrin vesicle coat	is part of	clathrin-coated vesicle	`GO:0030136` GO:0030136 defines clathrin-coated vesicles by a coat formed of clathrin.
clathrin vesicle coat	participates in	clathrin-dependent endocytosis	`GO:0072583` GO:0072583 describes endocytic uptake through clathrin-coated pits that form clathrin-coated endocytic vesicles. `DOI:10.1016/j.cell.2005.09.024` Kaksonen, Toret and Drubin 2005 analyzed the clathrin- and actin-mediated yeast endocytic machinery.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral groundings for clathrin heavy-chain and light-chain families, the clathrin triskelion, and yeast adaptor modules. This first clathrin vesicle coat record keeps core clathrin chains coarse and omits AP/GGA or yeast endocytic adaptor components until exact family and complex boundaries are reviewed.

Evidence

GO:0030125 Gene Ontology cellular-component term for the clathrin vesicle coat.
GO:0030120 Gene Ontology cellular-component parent for vesicle coats.
GO:0030136 Gene Ontology cellular-component term for clathrin-coated vesicles.
GO:0072583 Gene Ontology biological-process term for clathrin-dependent endocytosis.
DOI:10.1083/jcb.106.5.1453 Payne et al. 1988, Protein transport to the vacuole and receptor-mediated endocytosis by clathrin heavy chain-deficient yeast, Journal of Cell Biology.
DOI:10.1074/jbc.271.51.33123 Chu, Pishvaee and Payne 1996, The Light Chain Subunit Is Required for Clathrin Function in Saccharomyces cerevisiae, Journal of Biological Chemistry.
DOI:10.1016/j.devcel.2005.04.014 Newpher et al. 2005, In Vivo Dynamics of Clathrin and Its Adaptor-Dependent Recruitment to the Actin-Based Endocytic Machinery in Yeast, Developmental Cell.
DOI:10.1016/j.cell.2005.09.024 Kaksonen, Toret and Drubin 2005, A Modular Design for the Clathrin- and Actin-Mediated Endocytosis Machinery, Cell.

Curation history

2026-09-12T08:01:22Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-12T08:01:58Z codex · EXPANDED_RECORD — Added vesicle-coat parentage, clathrin-coated vesicle parthood, reviewed-label-only clathrin heavy- and light-chain components, Saccharomyces scope, clathrin-dependent endocytosis, DOI/GO evidence, a nonmechanistic endocytic assembly graph, and a triskelion/adaptor-grounding TODO.
2026-09-12T08:08:00Z codex · ADDRESSED_PR_REVIEW — Resolved PR #612 review issues #613 and #614 by removing an unmodeled Kukulski scission citation and narrowing the yeast assembly graph from the plasma membrane to cortical endocytic sites.

Source: data/structures/other/clathrin_vesicle_coat.yaml