cytoplasmic vesicle lumen

GO:0060205 · Membrane organelle · Subcellular region · Proposed

The volume enclosed by a cytoplasmic vesicle. [GO:0060205]

Part of: cytoplasmic vesicle (GO:0031410)

Xrefs: uniprot.location:SL-0325 — Cytoplasmic vesicle lumen

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding-yeast Cvt vesicles enclose a luminal cargo compartment inside a double membrane during cytoplasm-to-vacuole targeting. [DOI:10.1091/mbc.e03-07-0479]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model used to characterize early-secretory-pathway requirements for Cvt vesicle and autophagosome assembly. [DOI:10.1091/mbc.e03-07-0479]

The cytoplasmic vesicle membrane encloses the lumen inside the cytoplasmic vesicle.

Subject	Predicate	Object	Evidence
cytoplasmic vesicle lumen	is part of	cytoplasmic vesicle	`GO:0060205` GO:0060205 identifies cytoplasmic vesicle lumen as the volume enclosed by a cytoplasmic vesicle. `uniprot.location:SL-0325` — Cytoplasmic vesicle lumen UniProt SL-0325 places cytoplasmic vesicle lumen under cytoplasmic vesicle.
cytoplasmic vesicle membrane	encloses	cytoplasmic vesicle lumen	`GO:0030659` GO:0030659 identifies the membrane surrounding a cytoplasmic vesicle. `uniprot.location:SL-0325` — Cytoplasmic vesicle lumen UniProt SL-0325 describes the lumen as bounded by the cytoplasmic vesicle membrane.

GO:0060205 Gene Ontology cellular-component term for cytoplasmic vesicle lumen.
GO:0031983 Gene Ontology cellular-component parent term for vesicle lumen.
GO:0031410 Gene Ontology cellular-component term for the enclosing cytoplasmic vesicle.
GO:0030659 Gene Ontology cellular-component term for the cytoplasmic vesicle membrane bounding the lumen.
uniprot.location:SL-0325 — Cytoplasmic vesicle lumen UniProt Subcellular Location entry SL-0325 maps cytoplasmic vesicle lumen to GO:0060205 and places it under cytoplasmic vesicle.
DOI:10.1091/mbc.e03-07-0479 Reggiori et al. 2004, Early stages of the secretory pathway, but not endosomes, are required for Cvt vesicle and autophagosome assembly in Saccharomyces cerevisiae, Molecular Biology of the Cell.

2026-09-14T21:09:47Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-14T21:10:35Z codex · EXPANDED_RECORD — Aligned the definition with GO:0060205, added intracellular-organelle-lumen parentage, cytoplasmic-vesicle parthood, the UniProt SL-0325 xref, Saccharomyces scope, vesicle-lumen function, GO/UniProt/DOI evidence, and a nonmechanistic lumen-topology graph.
2026-09-14T21:22:57Z codex · ADDRESS_REVIEW — Resolved #897 by using GO:0031983 vesicle lumen as the nearest GO is-a parent; resolved #898 by removing the overbroad generic lumen cargo function and unused SL-0088 evidence.