ER to Golgi transport vesicle membrane

GO:0012507 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi apparatus. [GO:0012507]

Synonyms: COPII coated vesicle membrane

Part of: COPII-coated ER to Golgi transport vesicle (GO:0030134)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
ER to Golgi transport vesicle membrane lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Lipid-bilayer constituent of the ER to Golgi transport vesicle membrane that surrounds a COPII-coated ER-to-Golgi transport vesicle. `GO:0012507` GO:0012507 defines the ER to Golgi transport vesicle membrane as the lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi apparatus.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast forms COPII-coated ER-to-Golgi transport vesicles from endoplasmic-reticulum membranes using the Sec23/Sec24, Sec13/Sec31, and Sar1 COPII coat machinery. [PMID:8004676]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which Sec proteins were identified as COPII coat machinery that drives ER-derived vesicle budding. [PMID:8004676]

Mechanism graphs

ER to Golgi transport vesicle membrane topology (FUNCTION)

The ER to Golgi transport vesicle membrane is the lipid-bilayer boundary of the COPII-coated ER-to-Golgi transport vesicle formed during endoplasmic-reticulum membrane evagination.

Subject	Predicate	Object	Evidence
ER to Golgi transport vesicle membrane	is part of	COPII-coated ER to Golgi transport vesicle	`GO:0012507` GO:0012507 identifies the ER to Golgi transport vesicle membrane as part of a COPII-coated vesicle. `GO:0030134` GO:0030134 identifies the containing COPII-coated ER-to-Golgi transport vesicle.
ER to Golgi transport vesicle membrane	bounds	COPII-coated ER to Golgi transport vesicle	`GO:0012507` GO:0012507 defines the ER to Golgi transport vesicle membrane as the lipid bilayer surrounding the transport vesicle.
endoplasmic reticulum membrane	donates membrane to	ER to Golgi transport vesicle membrane	`GO:0090114` GO:0090114 defines COPII-coated vesicle budding as evagination of an endoplasmic reticulum membrane to form a COPII-coated vesicle. `PMID:9568718` Matsuoka et al. 1998 reconstituted COPII-coated vesicle formation on chemically defined liposomes.

Discussions

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the ER to Golgi transport vesicle membrane. The record is exactly grounded to GO:0012507, but the ER to Golgi transport vesicle membrane lipid-bilayer constituent is intentionally left as reviewed-label-only until an exact source-neutral lipid or membrane-constituent CURIE is curated.
INTERPRETATION (RESOLVED): Keep the COPII vesicle coat as a whole-vesicle part rather than as a lipid-bilayer membrane component. GO:0030127 denotes the COPII protein coat on the coated vesicle, whereas GO:0012507 denotes the transport vesicle membrane.

Evidence

GO:0012507 Gene Ontology cellular-component term for ER to Golgi transport vesicle membrane.
GO:0030658 Gene Ontology cellular-component parent term for transport vesicle membranes.
GO:0030662 Gene Ontology cellular-component parent term for coated vesicle membranes.
GO:0030134 Gene Ontology cellular-component term for the containing COPII-coated ER-to-Golgi transport vesicle.
GO:0005789 Gene Ontology cellular-component term for the endoplasmic reticulum membrane.
GO:0090114 Gene Ontology biological-process term for COPII-coated vesicle budding.
GO:0030127 Gene Ontology cellular-component term for the COPII vesicle coat.
PMID:8004676 Barlowe et al. 1994, 'COPII: A membrane coat formed by Sec proteins that drive vesicle budding from the endoplasmic reticulum', Cell.
PMID:9568718 Matsuoka et al. 1998, 'COPII-Coated Vesicle Formation Reconstituted with Purified Coat Proteins and Chemically Defined Liposomes', Cell.

Curation history

2026-09-14T18:58:59Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-14T18:59:42Z codex · EXPANDED_RECORD — Added GO transport/coated-vesicle membrane parentage, COPII-coated ER-to-Golgi vesicle parthood, the GO COPII-coated-vesicle membrane synonym, a reviewed-label-only lipid-bilayer component, Saccharomyces scope, GO/DOI evidence, a nonmechanistic ER-to-Golgi vesicle-membrane topology graph, and lipid-grounding plus COPII-coat boundary discussions.
2026-09-21T09:25:14Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1229 by routing Barlowe et al. 1994 COPII evidence through reachable PMID:8004676 instead of the unreadable Cell DOI.
2026-09-21T11:34:06Z codex · REPLACED_UNREADABLE_EVIDENCE — Resolved #1237 by routing Matsuoka et al. 1998 COPII liposome evidence through reachable PMID:9568718 instead of the unreadable Cell DOI.

Source: data/structures/membrane_organelle/er_to_golgi_transport_vesicle_membrane.yaml