Golgi-associated vesicle membrane

GO:0030660 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding a vesicle associated with the Golgi apparatus. [GO:0030660]

Synonyms: Golgi vesicle membrane

Part of: Golgi-associated vesicle (GO:0005798)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
Golgi-associated vesicle membrane lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Lipid-bilayer constituent of the Golgi-associated vesicle membrane that surrounds a Golgi-associated vesicle. `GO:0030660` GO:0030660 defines the Golgi-associated vesicle membrane as the lipid bilayer surrounding a Golgi-associated vesicle.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has a coatomer-dependent COPI system that retrieves dilysine-tagged early secretory cargo to the endoplasmic reticulum. [DOI:10.1016/0092-8674(94)90011-6]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which coatomer mutants established COPI roles in Golgi-to-ER retrieval and early secretory trafficking. [DOI:10.1016/0092-8674(94)90011-6]

Mechanism graphs

Golgi-associated vesicle membrane topology (FUNCTION)

The Golgi-associated vesicle membrane is the lipid bilayer that bounds Golgi-associated vesicles, including COPI-coated and trans-Golgi-network transport vesicles.

Subject	Predicate	Object	Evidence
Golgi-associated vesicle membrane	is part of	Golgi-associated vesicle	`GO:0030660` GO:0030660 defines this membrane as surrounding a Golgi-associated vesicle. `GO:0005798` GO:0005798 identifies the containing Golgi-associated vesicle.
Golgi-associated vesicle membrane	bounds	Golgi-associated vesicle	`GO:0030660` GO:0030660 defines the membrane as the lipid bilayer around a vesicle associated with the Golgi apparatus.
COPI-coated vesicle membrane	is a	Golgi-associated vesicle membrane	`GO:0030663` GO:0030663 identifies COPI-coated vesicle membranes as a child class of GO:0030660. `GO:0030660` GO:0030660 denotes the parent Golgi-associated vesicle membrane class.
trans-Golgi network transport vesicle membrane	is a	Golgi-associated vesicle membrane	`GO:0012510` GO:0012510 identifies trans-Golgi network transport vesicle membranes as a child class of GO:0030660. `GO:0030660` GO:0030660 denotes the parent Golgi-associated vesicle membrane class.
Golgi membrane	donates membrane to	COPI-coated vesicle membrane	`GO:0035964` GO:0035964 defines COPI-coated vesicle budding as evagination of a Golgi membrane to form a COPI-coated vesicle. `DOI:10.1016/0092-8674(91)90176-y` Serafini et al. 1991 analyzed coat proteins on Golgi-derived COP-coated vesicles.

Discussions

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the Golgi-associated vesicle membrane. The record is exactly grounded to GO:0030660, but the generic lipid-bilayer constituent is intentionally left reviewed-label-only until an exact lipid or membrane-constituent CURIE is curated.
INTERPRETATION (RESOLVED): Keep COPI coats and coatomer subunits off the generic Golgi-associated vesicle membrane record. GO:0030660 denotes the lipid-bilayer membrane that surrounds the vesicle, whereas GO:0030126 and COPI coat records model the protein coat on the whole COPI-coated vesicle.

Evidence

GO:0030660 Gene Ontology cellular-component term for the Golgi-associated vesicle membrane.
GO:0030659 Gene Ontology cellular-component parent term for cytoplasmic vesicle membranes.
GO:0005798 Gene Ontology cellular-component term for the containing Golgi-associated vesicle.
GO:0030663 Gene Ontology cellular-component child term for COPI-coated vesicle membranes.
GO:0012510 Gene Ontology cellular-component child term for trans-Golgi network transport vesicle membranes.
GO:0030137 Gene Ontology cellular-component term for COPI-coated vesicles.
GO:0000139 Gene Ontology cellular-component term for the Golgi membrane source of COPI-coated vesicle budding.
GO:0035964 Gene Ontology biological-process term for COPI-coated vesicle budding from Golgi membranes.
DOI:10.1016/0092-8674(91)90176-y Serafini et al. 1991, ADP-Ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles, Cell.
DOI:10.1016/0092-8674(94)90011-6 Letourneur et al. 1994, Coatomer is essential for retrieval of dilysine-tagged proteins to the endoplasmic reticulum, Cell.

Curation history

2026-09-16T06:16:17Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-16T06:17:03Z codex · EXPANDED_RECORD — Added cytoplasmic-vesicle-membrane parentage, Golgi-associated vesicle parthood, the GO related synonym, a reviewed-label-only lipid-bilayer component, Saccharomyces COPI scope, GO/DOI evidence, a nonmechanistic Golgi-associated vesicle membrane topology graph, and lipid-grounding plus COPI-coat boundary discussions.
2026-09-16T06:28:22Z codex · ADDRESSED_PR_REVIEW — Resolved PR #1070 review issue #1071 by representing the GO:0012510 trans-Golgi network transport vesicle membrane child in record-level evidence and the nonmechanistic topology graph.

Source: data/structures/membrane_organelle/golgi_associated_vesicle_membrane.yaml