trans-Golgi network transport vesicle membrane

GO:0012510 · Membrane organelle · Membrane · Proposed

The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell. [GO:0012510]

Synonyms: TGN transport vesicle membrane; trans-Golgi network constitutive secretory pathway transport vesicle membrane

Part of: GO:0030140 — trans-Golgi network transport vesicle (no local record)

Has part: clathrin coat of trans-Golgi network vesicle (GO:0030130)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
trans-Golgi network transport vesicle membrane lipid bilayer	Lipid	part of	Reviewed label only (reviewed name; no accession asserted)			ESSENTIAL	Lipid-bilayer constituent of the trans-Golgi network transport vesicle membrane that surrounds a TGN transport vesicle. `GO:0012510` GO:0012510 defines the trans-Golgi network transport vesicle membrane as the lipid bilayer surrounding a vesicle moving material between the TGN and other compartments.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Holthuis et al. characterized Tlg1p and Tlg2p as Saccharomyces syntaxins in the TGN/endosomal system. [DOI:10.1093/emboj/17.1.113]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which Ent3p and Ent5p adaptor functions in protein trafficking between the trans-Golgi network and endosomes were dissected. [DOI:10.1091/MBC.E06-11-1000]

Mechanism graphs

Trans-Golgi network transport vesicle membrane topology (FUNCTION)

The trans-Golgi network transport vesicle membrane is the clathrin-coated lipid-bilayer boundary of a TGN transport vesicle.

Subject	Predicate	Object	Evidence
trans-Golgi network transport vesicle membrane	is part of	trans-Golgi network transport vesicle	`GO:0012510` GO:0012510 identifies the TGN transport vesicle membrane. `GO:0030140` — trans-Golgi network transport vesicle GO:0030140 identifies the containing TGN transport vesicle.
trans-Golgi network transport vesicle membrane	bounds	trans-Golgi network transport vesicle	`GO:0012510` GO:0012510 defines this structure as the lipid bilayer surrounding a TGN transport vesicle.
clathrin coat of trans-Golgi network vesicle	is part of	trans-Golgi network transport vesicle membrane	`GO:0030130` GO:0030130 records the clathrin coat of a TGN vesicle as part of a GO:0012510 trans-Golgi network transport vesicle membrane.
trans-Golgi network transport vesicle membrane	supports	TGN/endosomal protein sorting	`GO:0012510` GO:0012510 identifies this membrane as surrounding vesicles that move material between the TGN and other compartments. `DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 studied Ent3p/Ent5p functions in yeast trafficking between the TGN and endosomes.
TGN/endosomal protein sorting	connects	trans-Golgi network	`GO:0012510` GO:0012510 identifies this membrane as surrounding vesicles that transport substances between the TGN and other parts of the cell. `DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 framed Ent3p/Ent5p adaptor roles as cargo-specific trafficking between the TGN and endosomes.
TGN/endosomal protein sorting	connects	endosome	`DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 framed Ent3p/Ent5p adaptor roles as cargo-specific trafficking between the TGN and endosomes.

Discussions

CURATION_TODO (OPEN): Resolve an exact source-neutral grounding for the lipid constituent of the trans-Golgi network transport vesicle membrane. The record is exactly grounded to GO:0012510, but the TGN transport vesicle membrane lipid-bilayer constituent is intentionally left reviewed-label-only until an exact source-neutral lipid or membrane-constituent CURIE is curated.
INTERPRETATION (RESOLVED): Keep the clathrin coat of TGN vesicles as a structural part rather than a lipid-bilayer component. GO:0030130 denotes the protein coat part of the membrane, whereas GO:0012510 denotes the vesicle-bounding lipid bilayer membrane.

Evidence

GO:0012510 Gene Ontology cellular-component term for trans-Golgi network transport vesicle membranes.
GO:0030658 Gene Ontology cellular-component direct parent term for transport vesicle membranes.
GO:0030660 Gene Ontology cellular-component direct parent term for Golgi-associated vesicle membranes.
GO:0030665 Gene Ontology cellular-component direct parent term for clathrin-coated vesicle membranes.
GO:0030140 — trans-Golgi network transport vesicle Gene Ontology cellular-component term for the containing trans-Golgi network transport vesicle.
GO:0030130 Gene Ontology cellular-component term for the clathrin coat of a trans-Golgi network vesicle that is part of the TGN transport vesicle membrane.
GO:0005802 Gene Ontology cellular-component term for the trans-Golgi network.
GO:0005768 Gene Ontology cellular-component term for endosomes.
DOI:10.1093/emboj/17.1.113 Holthuis et al. 1998, 'Two syntaxin homologues in the TGN/endosomal system of yeast', EMBO Journal.
DOI:10.1091/MBC.E06-11-1000 Copic et al. 2007, 'Ent3p and Ent5p exhibit cargo-specific functions in trafficking proteins between the trans-Golgi network and the endosomes in yeast', Molecular Biology of the Cell.

Curation history

2026-09-16T06:45:08Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-16T06:46:24Z codex · EXPANDED_RECORD — Added GO transport/Golgi-associated/clathrin-coated vesicle membrane parentage, TGN transport vesicle parthood, the GO exact synonyms, a reviewed-label-only lipid-bilayer component, Saccharomyces TGN/endosome traffic scope, GO/DOI evidence, a nonmechanistic TGN transport vesicle membrane topology graph, and lipid-grounding plus clathrin-coat boundary discussions.
2026-09-16T06:58:53Z codex · ADDRESSED_PR_REVIEW — Resolved PR #1072 review issue #1073 by connecting the trans-Golgi network node into the nonmechanistic TGN transport vesicle membrane topology graph.

Source: data/structures/membrane_organelle/trans_golgi_network_transport_vesicle_membrane.yaml