clathrin coat of trans-Golgi network vesicle

GO:0030130 · Other · Multiprotein complex · Proposed

A clathrin coat found on a vesicle of the trans-Golgi network. [GO:0030130]

Synonyms: clathrin coat of TGN vesicle

Part of: trans-Golgi network transport vesicle membrane (GO:0012510)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
clathrin triskelion scaffold	Protein complex	part of	Reviewed label only (reviewed name; no accession asserted)			UNKNOWN	Core clathrin triskelion lattice that polymerizes into the coat on a trans-Golgi-network transport vesicle. `GO:0030130` GO:0030130 defines this structure as a clathrin coat on a TGN vesicle. `GO:0030118` GO:0030118 defines clathrin coats as polymerized clathrin triskelions linked to membranes by adaptor complexes.
TGN clathrin adaptor and cargo-selection factors	Protein	part of	Reviewed label only (reviewed name; no accession asserted)			UNKNOWN	Adaptor proteins that connect TGN clathrin coat assembly to vesicle membranes and cargo sorting. `GO:0030118` GO:0030118 frames clathrin coats as linked to membranes through adaptor complexes. `GO:0030119` GO:0030119 identifies AP-type membrane coat adaptor complexes as membrane-coat components that link clathrin or another coat-forming molecule to a membrane surface. `DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 studied Ent3p/Ent5p adaptor functions in yeast trafficking between the TGN and endosomes.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast has Ent3p and Ent5p adaptor functions in protein trafficking between the trans-Golgi network and endosomes. [DOI:10.1091/MBC.E06-11-1000]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which TGN/endosomal Ent3p and Ent5p adaptor functions were dissected. [DOI:10.1091/MBC.E06-11-1000]

Mechanism graphs

TGN clathrin coat is carried by a TGN vesicle membrane (FUNCTION)

The clathrin coat of a trans-Golgi-network vesicle is a clathrin/adaptor protein coat on a TGN transport-vesicle membrane.

Subject	Predicate	Object	Evidence
clathrin triskelion scaffold	polymerizes into	clathrin coat of trans-Golgi network vesicle	`GO:0030118` GO:0030118 defines clathrin coats as polymerized clathrin triskelions. `GO:0030130` GO:0030130 identifies the TGN vesicle-specific clathrin coat.
TGN clathrin adaptor and cargo-selection factors	links scaffold to	trans-Golgi network transport vesicle membrane	`GO:0030119` GO:0030119 defines AP-type adaptors as linking clathrin or another coat-forming molecule to a membrane surface. `DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 studied Ent3p/Ent5p adaptor functions in TGN-to-endosome protein trafficking.
TGN clathrin adaptor and cargo-selection factors	is part of	clathrin coat of trans-Golgi network vesicle	`GO:0030118` GO:0030118 defines clathrin coats as clathrin triskelions linked to membranes through adaptor complexes. `GO:0030130` GO:0030130 identifies the TGN vesicle-specific clathrin coat. `DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 studied Ent3p/Ent5p adaptor functions in trafficking between the TGN and endosomes.
clathrin coat of trans-Golgi network vesicle	is part of	trans-Golgi network transport vesicle membrane	`GO:0030130` GO:0030130 records the TGN clathrin coat as part of the GO:0012510 TGN transport-vesicle membrane.
trans-Golgi network transport vesicle membrane	is part of	trans-Golgi network transport vesicle	`GO:0012510` GO:0012510 identifies the TGN transport-vesicle membrane. `GO:0030140` — trans-Golgi network transport vesicle GO:0030140 identifies the containing TGN transport vesicle.
clathrin coat of trans-Golgi network vesicle	supports	TGN/endosomal protein sorting	`DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 framed Ent3p/Ent5p adaptor roles as cargo-specific trafficking between the TGN and endosomes.
TGN/endosomal protein sorting	connects	trans-Golgi network	`GO:0030130` GO:0030130 identifies a clathrin coat on a TGN vesicle. `DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 studied adaptor functions in TGN/endosomal trafficking.
TGN/endosomal protein sorting	connects	endosome	`DOI:10.1091/MBC.E06-11-1000` Copic et al. 2007 studied cargo-specific protein trafficking between the TGN and endosomes.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral groundings for TGN-vesicle clathrin triskelions and adaptor/cargo-selection factors. GO:0030130 exactly grounds the TGN-vesicle clathrin coat, but this initial pass keeps its triskelion scaffold and membrane/cargo adaptor classes reviewed-label-only until exact source-neutral complex or protein-family identifiers are curated.
INTERPRETATION (RESOLVED): Keep the TGN-specific clathrin-coat record distinct from the broader clathrin vesicle coat record. GO:0030130 is the clathrin coat on trans-Golgi-network vesicles, whereas GO:0030125 is the broader clathrin vesicle coat parent over endocytic, synaptic, and TGN vesicle subclasses.

Evidence

GO:0030130 Gene Ontology cellular-component term for the clathrin coat of a trans-Golgi network vesicle.
GO:0030125 Gene Ontology cellular-component parent term for clathrin vesicle coats.
GO:0030118 Gene Ontology cellular-component term for clathrin coats.
GO:0030119 Gene Ontology cellular-component term for AP-type membrane coat adaptor complexes.
GO:0012510 Gene Ontology cellular-component term for the TGN transport vesicle membrane that carries GO:0030130 as a part.
GO:0030140 — trans-Golgi network transport vesicle Gene Ontology cellular-component term for the containing trans-Golgi network transport vesicle.
GO:0005802 Gene Ontology cellular-component term for the trans-Golgi network.
GO:0005768 Gene Ontology cellular-component term for endosomes.
DOI:10.1091/MBC.E06-11-1000 Copic et al. 2007, 'Ent3p and Ent5p exhibit cargo-specific functions in trafficking proteins between the trans-Golgi network and the endosomes in yeast', Molecular Biology of the Cell.

Curation history

2026-09-16T07:17:05Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-16T07:18:32Z codex · EXPANDED_RECORD — Added clathrin-vesicle-coat parentage, TGN transport-vesicle membrane parthood, the GO exact synonym, reviewed-label-only triskelion and adaptor components, Saccharomyces TGN/endosome traffic scope, GO/DOI evidence, a nonmechanistic TGN clathrin-coat topology graph, and grounding plus scope boundary discussions.
2026-09-16T07:28:59Z codex · ADDRESSED_PR_REVIEW — Resolved PR #1074 review issue #1075 by adding an evidence-backed edge that makes TGN clathrin adaptor and cargo-selection factors explicit parts of the TGN clathrin coat in the topology graph.

Source: data/structures/other/clathrin_coat_of_trans_golgi_network_vesicle.yaml