cellular bud tip

GO:0005934 · Other · Subcellular region · Proposed

The distal region of a cellular bud opposite the mother-cell attachment site. [GO:0005934]

Synonyms: bud tip

Part of: cellular bud (GO:0005933)

Xrefs: uniprot.location:SL-0030 — Bud tip

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast localizes Sec6/Sec8/Sec15 exocyst material to the distal tip of small buds during bud growth. [DOI:10.1083/jcb.130.2.299]

NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which Sec6, Sec8, and Sec15 exocyst subunits localize to small bud tips. [DOI:10.1083/jcb.130.2.299]

polarized bud-tip growth site — The cellular bud tip is the distal bud region where polarized exocytic and polarity machinery localizes during budding-yeast growth.
- GO:0005934 GO:0005934 identifies the cellular bud tip.
- DOI:10.1083/jcb.130.2.299 TerBush and Novick 1995 localized the Sec6/Sec8/Sec15 complex to small bud tips in Saccharomyces cerevisiae.
- DOI:10.1083/jcb.135.3.725 Valtz and Herskowitz 1996 showed Pea2 and Spa2 polarity-protein localization at budding growth sites.

The cellular bud tip is the distal bud region where the budding-yeast exocyst localizes during polarized growth.

Subject	Predicate	Object	Evidence
cellular bud tip	is part of	cellular bud	`GO:0005934` GO:0005934 identifies the cellular bud tip. `uniprot.location:SL-0030` — Bud tip UniProt SL-0030 places the bud tip under the Bud location.
exocyst	localizes to	cellular bud tip	`DOI:10.1083/jcb.130.2.299` TerBush and Novick 1995 identified Sec6p, Sec8p, and Sec15p at small bud tips.

INTERPRETATION (RESOLVED): Keep polarisome and exocyst proteins on their own structure records rather than duplicating them as cellular bud tip components. GO:0005934 and UniProt SL-0030 identify the distal bud-tip region. The cellular bud tip polarisome and the exocyst are localized complexes, so this regional record cites them as localized machinery without duplicating their protein subunits.

GO:0005934 Gene Ontology cellular-component term for the cellular bud tip.
GO:0005933 Gene Ontology cellular-component term for the cellular bud.
GO:0000145 Gene Ontology cellular-component term for the exocyst.
GO:0031561 Gene Ontology cellular-component term for the cellular bud tip polarisome.
uniprot.location:SL-0030 — Bud tip UniProt Subcellular Location entry SL-0030 maps Bud tip to GO:0005934 and places the bud tip under Bud.
uniprot.location:SL-0027 — Bud UniProt Subcellular Location entry SL-0027 maps the parent Bud location to GO:0005933.
DOI:10.1083/jcb.130.2.299 TerBush and Novick 1995, 'Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae', Journal of Cell Biology.
DOI:10.1083/jcb.135.3.725 Valtz and Herskowitz 1996, 'Pea2 protein of yeast is localized to sites of polarized growth and is required for efficient mating and bipolar budding', Journal of Cell Biology.

2026-09-15T01:42:11Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-15T01:42:59Z codex · EXPANDED_RECORD — Added UniProt bud-tip synonymy and xref, cellular-bud parthood, Saccharomyces cerevisiae distribution and example evidence, a polarized bud-tip growth-site function, GO/UniProt/DOI evidence, a nonmechanistic bud-tip exocyst topology graph, and an exocyst/polarisome component-boundary decision.
2026-09-15T01:52:54Z codex · ADDRESSED_REVIEW — Resolved #917 by narrowing the Saccharomyces cerevisiae taxonomic-distribution note to the small-bud-tip exocyst observation directly supported by DOI:10.1083/jcb.130.2.299.