cellular bud

GO:0005933 · Other · Other · Proposed

A cellular outgrowth formed during budding reproduction that remains connected to a mother cell while it grows into a new individual. [GO:0005933]

Synonyms: bud; growing bud

Has part: cellular bud membrane (GO:0033101); cellular bud neck (GO:0005935); cellular bud tip (GO:0005934)

Xrefs: uniprot.location:SL-0027 — Bud

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Taxonomic distribution

• NCBITaxon:4932 Saccharomyces cerevisiae — COMMON: Budding yeast forms mother-attached cellular buds during mitotic polarized growth before cytokinesis separates mother and daughter. [DOI:10.3389/fcell.2016.00123]

Canonical examples

• NCBITaxon:4932 Saccharomyces cerevisiae — Budding-yeast model in which Pea2 and Spa2 polarity proteins localize to polarized-growth sites during budding. [DOI:10.1083/jcb.135.3.725]

Functions

• budding growth — The cellular bud is the daughter-cell outgrowth that expands by polarized growth before cytokinesis separates it from the mother yeast cell.
  • DOI:10.1083/jcb.135.3.725 Valtz and Herskowitz 1996 studied bipolar and mating-projection growth through Saccharomyces polarity proteins that localize to budding sites.
  • DOI:10.3389/fcell.2016.00123 Glomb and Gronemeyer 2016 review the mother-bud neck as the cortical cytokinesis site organized during budding-yeast growth.

Mechanism graphs

Cellular bud topology (FUNCTION)

The yeast cellular bud has a surrounding bud membrane, a distal bud tip, and a bud neck that constricts the connection between the mother and daughter cell.

Evidence

• GO:0005933 Gene Ontology cellular-component term for the cellular bud.
• GO:0033101 Gene Ontology cellular-component term for the cellular bud membrane.
• GO:0005935 Gene Ontology cellular-component term for the cellular bud neck.
• GO:0005934 Gene Ontology cellular-component term for the cellular bud tip.
• uniprot.location:SL-0027 — Bud UniProt Subcellular Location entry SL-0027 maps Bud to GO:0005933 and lists Growing bud as a synonym.
• uniprot.location:SL-0028 — Bud membrane UniProt Subcellular Location entry SL-0028 maps Bud membrane to GO:0033101 and places the bud membrane under Bud.
• uniprot.location:SL-0029 — Bud neck UniProt Subcellular Location entry SL-0029 maps Bud neck to GO:0005935 and places the bud neck under Bud.
• uniprot.location:SL-0030 — Bud tip UniProt Subcellular Location entry SL-0030 maps Bud tip to GO:0005934 and places the bud tip under Bud.
• DOI:10.1083/jcb.135.3.725 Valtz and Herskowitz 1996, Pea2 protein of yeast is localized to sites of polarized growth and is required for efficient mating and bipolar budding, Journal of Cell Biology.
• DOI:10.3389/fcell.2016.00123 Glomb and Gronemeyer 2016, Septin Organization and Functions in Budding Yeast, Frontiers in Cell and Developmental Biology.

Curation history

• 2026-09-14T23:30:49Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
• 2026-09-14T23:31:21Z codex · EXPANDED_RECORD — Added UniProt growing-bud synonymy, bud membrane/neck/tip parts, the UniProt SL-0027 xref, budding-yeast distribution and example evidence, a budding-growth function, GO/UniProt/DOI evidence, and a nonmechanistic cellular-bud topology graph.
• 2026-09-14T23:45:45Z codex · ADDRESSED_REVIEW — Resolved #906 by narrowing the Saccharomyces cerevisiae canonical example to the Pea2/Spa2 budding-site localization claim supported by DOI:10.1083/jcb.135.3.725.

Source: data/structures/other/cellular_bud.yaml