GATOR2 complex

GO:0061700 · Other · Multiprotein complex · Proposed

A multiprotein subcomplex of the GATOR complex that regulates TORC1 signaling by interacting with the Rag GTPase. In human, this complex consists of WDR24, WDR59, MIOS, SEH1L, and SEC13. In S. cerevisiae, this complex is referred to as SEACAT and contains the Sea2p, Sea3p, Sea4p, Seh1p, Sec13p proteins. [GO:0061700]

Synonyms: SEACAT complex

Part of: Seh1-associated complex (GO:0035859)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Essential	Role
Sea2 GATOR2 subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SEA2	UNKNOWN	GATOR2/SEACAT subunit assigned to the yeast SEA/GATOR branch kept separate from the Iml1/Npr2/Npr3 GATOR1/SEACIT GAP complex. `GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
Sea3 GATOR2 subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SEA3	UNKNOWN	GATOR2/SEACAT subunit assigned with Sea2, Sea4, Seh1 and Sec13 to the yeast SEACAT side of the SEA/GATOR complex. `GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
Sea4 GATOR2 subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SEA4	UNKNOWN	GATOR2/SEACAT subunit assigned with Sea2, Sea3, Seh1 and Sec13 to the yeast SEACAT side of the SEA/GATOR complex. `GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
Seh1 GATOR2 subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SEH1	UNKNOWN	Shared Seh1 beta-propeller represented here in its GATOR2/SEACAT constituent context. `GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
Sec13 GATOR2 subunit	Protein	part of	Reviewed label only (reviewed name; no accession asserted)	SEC13	UNKNOWN	Shared Sec13 beta-propeller represented here in its GATOR2/SEACAT constituent context. `GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — VARIABLE: Budding yeast is the curated model for the Seh1/Sec13/Sea2/Sea3/Sea4 SEACAT subcomplex in the SEA/GATOR system. [GO:0061700]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Yeast model in which the SEACAT branch of the SEA/GATOR complex is represented by Sea2, Sea3, Sea4, Seh1 and Sec13. [GO:0061700]

Functions

positive regulation of TORC1 signaling GO:1904263 — Yeast GATOR2/SEACAT is represented as a positive TORC1-signaling regulator because SEACAT antagonizes the GATOR1/SEACIT branch of the SEA/GATOR complex.
- GO:1904263 Gene Ontology biological-process term for positive regulation of TORC1 signaling.
- GO:0061700 Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart.
- DOI:10.1126/science.1232044 Bar-Peled et al. 2013 separated human GATOR into GATOR1 and GATOR2 subcomplexes that regulate Rag-dependent amino-acid-sensitive mTORC1 signaling.
- DOI:10.4161/cc.26000 Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.

Mechanism graphs

GATOR2/SEACAT supports TORC1 signaling (REGULATION)

In Saccharomyces cerevisiae, Sea2, Sea3, Sea4, Seh1 and Sec13 form a SEACAT/GATOR2 branch of the SEA/GATOR complex linked to Rag-family TORC1 regulation.

Subject	Predicate	Object	Evidence
Sea2 GATOR2 subunit	is part of	GATOR2 complex	`GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
Sea3 GATOR2 subunit	is part of	GATOR2 complex	`GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
Sea4 GATOR2 subunit	is part of	GATOR2 complex	`GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
Seh1 GATOR2 subunit	is part of	GATOR2 complex	`GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
Sec13 GATOR2 subunit	is part of	GATOR2 complex	`GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
GATOR2 complex	positively regulates	TORC1 signaling	`GO:1904263` Gene Ontology biological-process term for positive regulation of TORC1 signaling. `GO:0061700` Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart. `DOI:10.1126/science.1232044` Bar-Peled et al. 2013 separated human GATOR into GATOR1 and GATOR2 subcomplexes that regulate Rag-dependent amino-acid-sensitive mTORC1 signaling. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.

Discussions

CURATION_TODO (OPEN): Resolve exact source-neutral InterPro, Pfam, or NCBIfam groundings for the five yeast GATOR2/SEACAT subunit classes. This first GATOR2 record names the yeast Sea2, Sea3, Sea4, Seh1 and Sec13 constituent subunits but leaves family grounding unset until exact orthology and shared-subunit boundaries are reviewed per subunit.
CURATION_TODO (RESOLVED): Keep the GATOR1/SEACIT GAP subcomplex outside this GATOR2/SEACAT record. GO separates GATOR2/SEACAT from GATOR1/SEACIT, and Bar-Peled et al. 2013 separated human GATOR into two subcomplexes; the Iml1/Npr2/Npr3 GAP branch therefore belongs in the distinct GATOR1 record.
CURATION_TODO (RESOLVED): Treat Seh1 and Sec13 as GATOR2/SEACAT constituent classes only in this record, despite their other complex contexts. Seh1 and Sec13 are shared beta-propeller proteins, so this record names their SEACAT role without asserting that all Seh1 or Sec13 pools are part of GATOR2.

Evidence

GO:0061700 Gene Ontology cellular-component term for the GATOR2 complex, including the Saccharomyces cerevisiae SEACAT counterpart.
GO:0032991 Gene Ontology cellular-component parent term for protein-containing complexes.
GO:0035859 Gene Ontology cellular-component term for the Seh1-associated SEA/GATOR complex.
GO:1904263 Gene Ontology biological-process term for positive regulation of TORC1 signaling.
GO:0038202 Gene Ontology biological-process term for TORC1 signaling.
DOI:10.4161/cc.26000 Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes and described SEACAT as a Seh1/Sea2-4/Sec13 GATOR2 counterpart that antagonizes SEACIT in TORC1 signaling.
DOI:10.1126/science.1232044 Bar-Peled et al. 2013 separated human GATOR into GATOR1 and GATOR2 subcomplexes that regulate Rag-dependent amino-acid-sensitive mTORC1 signaling.

Curation history

2026-09-18T09:29:40Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-18T09:30:36Z codex · EXPANDED_RECORD — Added GATOR2/SEACAT synonymy, protein-complex parentage, Seh1-associated-complex parthood, reviewed-label-only yeast Sea2/Sea3/Sea4/Seh1/Sec13 components, Saccharomyces scope, a positive TORC1-signaling function, GO/DOI evidence, a nonmechanistic TORC1-regulation graph, and sibling/shared-subunit boundary discussions.
2026-09-18T09:42:48Z codex · ADDRESSED_PR_REVIEW — #1137: Repointed SEACAT branch evidence from the GATOR1 Science Signaling DOI to the Cell Cycle DOI that explicitly names SEACAT and describes its Seh1/Sea2-4/Sec13 membership.
2026-09-18T09:55:10Z codex · ADDRESSED_PR_REVIEW — #1138/#1139/#1140: Added yeast SEACAT evidence to the TORC1 function and graph edge, narrowed the Saccharomyces taxonomic presence qualifier, and normalized the initial creation-history sections.

Source: data/structures/other/gator2_complex.yaml