Seh1-associated complex

GO:0035859 · Other · Multiprotein complex · Proposed

A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p. [GO:0035859]

Synonyms: GATOR complex; SEA complex

Has part: GATOR1 complex (GO:1990130); GATOR2 complex (GO:0061700)

UniProt location names: UniProt Consortium, CC BY 4.0. Reference label and route sources.

Components

Component	Type	Part of / acts on	Grounding	Genes	Stoichiometry	Essential	Role
GATOR1 complex	Protein complex	part of	`GO:1990130`			UNKNOWN	Negative-regulatory GATOR branch corresponding to the yeast Iml1/Npr2/Npr3 SEACIT subcomplex. `GO:0035859` Gene Ontology cellular-component term for the Seh1-associated SEA/GATOR complex. `GO:1990130` Gene Ontology cellular-component term for the GATOR1/SEACIT subcomplex. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes in the SEA/GATOR complex and connected them to Rag-family TORC1 regulation.
GATOR2 complex	Protein complex	part of	`GO:0061700`			UNKNOWN	Positive-regulatory GATOR branch corresponding to the yeast Seh1/Sec13/Sea2/Sea3/Sea4 SEACAT subcomplex. `GO:0035859` Gene Ontology cellular-component term for the Seh1-associated SEA/GATOR complex. `GO:0061700` Gene Ontology cellular-component term for the GATOR2/SEACAT subcomplex. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes in the SEA/GATOR complex and connected them to Rag-family TORC1 regulation.

Taxonomic distribution

NCBITaxon:4932 Saccharomyces cerevisiae — VARIABLE: Budding yeast is the curated model for the Seh1-associated SEA/GATOR complex that contains SEACIT and SEACAT branches upstream of Rag-family TORC1 regulation. [GO:0035859]

Canonical examples

NCBITaxon:4932 Saccharomyces cerevisiae — Yeast model in which the SEA/GATOR complex was identified as a Seh1/Sec13-containing vacuole-associated coatomer-related complex. [DOI:10.1074/mcp.M110.006478]

Functions

TORC1 signaling GO:0038202 — The yeast SEA/GATOR complex organizes GATOR1/SEACIT and GATOR2/SEACAT branches that regulate Rag-family TORC1 signaling.
- GO:0038202 Gene Ontology biological-process term for TORC1 signaling.
- GO:0035859 Gene Ontology cellular-component term for the Seh1-associated SEA/GATOR complex.
- DOI:10.4161/cc.26000 Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes in the SEA/GATOR complex and connected them to Rag-family TORC1 regulation.

Mechanism graphs

SEA/GATOR contains SEACIT and SEACAT branches (REGULATION)

In Saccharomyces cerevisiae, the Seh1-associated SEA/GATOR complex contains GATOR1/SEACIT and GATOR2/SEACAT branches that regulate Rag-family TORC1 signaling.

Subject	Predicate	Object	Evidence
GATOR1 complex	is part of	Seh1-associated complex	`GO:0035859` Gene Ontology cellular-component term for the Seh1-associated SEA/GATOR complex. `GO:1990130` Gene Ontology cellular-component term for the GATOR1/SEACIT subcomplex. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes in the SEA/GATOR complex and connected them to Rag-family TORC1 regulation.
GATOR2 complex	is part of	Seh1-associated complex	`GO:0035859` Gene Ontology cellular-component term for the Seh1-associated SEA/GATOR complex. `GO:0061700` Gene Ontology cellular-component term for the GATOR2/SEACAT subcomplex. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes in the SEA/GATOR complex and connected them to Rag-family TORC1 regulation.
Seh1-associated complex	regulates	TORC1 signaling	`GO:0038202` Gene Ontology biological-process term for TORC1 signaling. `GO:0035859` Gene Ontology cellular-component term for the Seh1-associated SEA/GATOR complex. `DOI:10.4161/cc.26000` Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes in the SEA/GATOR complex and connected them to Rag-family TORC1 regulation.

Discussions

CURATION_TODO (RESOLVED): Keep individual Iml1, Npr2, Npr3, Sea2, Sea3, Sea4, Seh1 and Sec13 protein rows in the GATOR1 and GATOR2 child records. GO already splits the SEA/GATOR complex into GATOR1/SEACIT and GATOR2/SEACAT subcomplexes, and those child records curate the yeast protein constituents with their own grounding discussions.

Evidence

GO:0035859 Gene Ontology cellular-component term for the Seh1-associated SEA/GATOR complex.
GO:0032991 Gene Ontology cellular-component parent term for protein-containing complexes.
GO:1990130 Gene Ontology cellular-component term for the GATOR1/SEACIT subcomplex.
GO:0061700 Gene Ontology cellular-component term for the GATOR2/SEACAT subcomplex.
GO:0038202 Gene Ontology biological-process term for TORC1 signaling.
DOI:10.1074/mcp.M110.006478 Dokudovskaya et al. 2011 identified the conserved coatomer-related SEA complex containing Sec13 and Seh1 and found that it dynamically associates with the Saccharomyces cerevisiae vacuole.
DOI:10.4161/cc.26000 Panchaud, Peli-Gulli and De Virgilio 2013 named the yeast SEACIT and SEACAT subcomplexes in the SEA/GATOR complex and connected them to Rag-family TORC1 regulation.

Curation history

2026-09-18T13:04:45Z codex · CREATED_RECORD — Scaffolded by scripts/new_record.py
2026-09-18T13:05:42Z codex · EXPANDED_RECORD — Added SEA/GATOR synonymy, protein-complex parentage, GATOR1 and GATOR2 parthood, exact GO-grounded GATOR1/SEACIT and GATOR2/SEACAT complex components, Saccharomyces scope, a TORC1 signaling function, GO/DOI evidence, a nonmechanistic SEACIT/SEACAT regulation graph, and an individual-protein boundary discussion.
2026-09-18T13:06:23Z codex · REFORMATTED_RECORD — Expanded shared YAML evidence aliases into plain repeated mappings.
2026-09-18T13:12:59Z codex · FIX_ID_LABELS — Aligned GATOR1 and GATOR2 component/node labels with their GO canonical labels while preserving SEACIT/SEACAT terminology in the explanatory text.

Source: data/structures/other/seh1_associated_complex.yaml