DUFMech

All families / PF08409

PF08409: TMTC_DUF1736

Protein O-mannosyl-transferase TMTC, DUF1736

Curation status
SEEDED
Seed status
UNKNOWN CANDIDATE
Characterization
UNSCORED

Grounding

PF08409: Protein O-mannosyl-transferase TMTC, DUF1736
IPR013618: integrated entry for Protein O-mannosyl-transferase TMTC, DUF1736

Source description

This domain of unknown function is found in O-mannosyl -transferases TMTC1-4, and constitutes a loop between TM7 and TM8 located in the ER lumen that contains a small hydrophobic, but not membrane-embedded helix. This loop is critical for catalysis and binding of ligands, especially the lipid-linked sugar moiety [InterPro reference PUB00098068]. TMTCs transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases acting primarily on the cadherin superfamily; each member has distinct roles in decorating the cadherin domains with O-linked mannose glycans at specific regions. These proteins also act as O-mannosyl-transferase on other proteins such as PDIA3 [InterPro reference PUB00098069].

Evidence and references

Source descriptions and links are provenance, not independent functional validation.

Evidence counts: not scored.

Curated functional assertions

No curated functional assertions supplied.

Protein sequence examples

9 verified sequence examples. FASTA

UniProtProtein / organismSequenceProvenance
Q20144Protein O-mannosyl-transferase F38B6.6
Caenorhabditis elegans
690 aa; version 2
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q56A06Protein O-mannosyl-transferase TMTC2
Mus musculus
836 aa; version 1
UniProt 2026_03
PTM REGISTRY MIRROR
3 sibling references
Q5T4D3Protein O-mannosyl-transferase TMTC4
Homo sapiens
741 aa; version 2
UniProt 2026_03
UNIPROT FETCH
3 sibling references
Q6ZXV5Protein O-mannosyl-transferase TMTC3
Homo sapiens
915 aa; version 2
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q7K4B6Protein O-mannosyl-transferase Tmtc3
Drosophila melanogaster
926 aa; version 1
UniProt 2026_03
UNIPROT FETCH
1 sibling references
Q8BG19Protein O-mannosyl-transferase TMTC4
Mus musculus
741 aa; version 1
UniProt 2026_03
UNIPROT FETCH
5 sibling references
Q8BRH0Protein O-mannosyl-transferase TMTC3
Mus musculus
920 aa; version 2
UniProt 2026_03
UNIPROT FETCH
4 sibling references
Q8N394Protein O-mannosyl-transferase TMTC2
Homo sapiens
836 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references
Q9VF81Protein O-mannosyl-transferase Tmtc4
Drosophila melanogaster
705 aa; version 1
UniProt 2026_03
UNIPROT FETCH
2 sibling references

Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.

Sequences and metadata: UniProt Consortium, CC BY 4.0.

Domain matches

No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.

Snapshot counters

proteins
6,936
matches
6,939
proteomes
1,367
taxa
4,389
structures
0
alphafold models
6,079
domain architectures
1,307

Classification basis

name matches duf; description says unknown function; domain of unknown function

No scoring reasons supplied.

Related Mech records

FamilyMechRecordProteinLink basis
TMTC_DUF1736 (PF08409)ProteinTraitsMechdolichyl-phosphate-mannose-protein mannosyltransferase activityQ8BRH0
Protein O-mannosyl-transferase TMTC3
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechbud outgrowth involved in lung branchingQ8BRH0
Protein O-mannosyl-transferase TMTC3
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechouter hair cell apoptotic processQ8BG19
Protein O-mannosyl-transferase TMTC4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechpositive regulation of endoplasmic reticulum calcium ion concentrationQ8BG19
Protein O-mannosyl-transferase TMTC4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechregulation of macromolecule metabolic processQ7K4B6
Protein O-mannosyl-transferase Tmtc3
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q20144
Protein O-mannosyl-transferase F38B6.6
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q56A06
Protein O-mannosyl-transferase TMTC2
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q5T4D3
Protein O-mannosyl-transferase TMTC4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q6ZXV5
Protein O-mannosyl-transferase TMTC3
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q8BG19
Protein O-mannosyl-transferase TMTC4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q8BRH0
Protein O-mannosyl-transferase TMTC3
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q8N394
Protein O-mannosyl-transferase TMTC2
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q9VF81
Protein O-mannosyl-transferase Tmtc4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736
trait identifier
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q20144
Protein O-mannosyl-transferase F38B6.6
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q56A06
Protein O-mannosyl-transferase TMTC2
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q5T4D3
Protein O-mannosyl-transferase TMTC4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q6ZXV5
Protein O-mannosyl-transferase TMTC3
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q8BG19
Protein O-mannosyl-transferase TMTC4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q8BRH0
Protein O-mannosyl-transferase TMTC3
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q8N394
Protein O-mannosyl-transferase TMTC2
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736Q9VF81
Protein O-mannosyl-transferase Tmtc4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechProtein O-mannosyl-transferase TMTC, DUF1736
trait identifier
TMTC_DUF1736 (PF08409)ProteinTraitsMechTetratricopeptide repeatQ5T4D3
Protein O-mannosyl-transferase TMTC4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechTetratricopeptide repeatQ6ZXV5
Protein O-mannosyl-transferase TMTC3
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechTetratricopeptide repeatQ8BG19
Protein O-mannosyl-transferase TMTC4
canonical example family classification
TMTC_DUF1736 (PF08409)ProteinTraitsMechTetratricopeptide repeatQ6ZXV5
Protein O-mannosyl-transferase TMTC3
canonical example family classification

Curation history and reviews

No retained curation events supplied.

No retained review supplied.

Record source

data/families/PF08409.yaml
Family YAML in this build

Download this family (JSON)

Status and evidence

Seed status
A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
Characterization
A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
Evidence counts
Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
Curation status
Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
Missing counts
Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.