All families / PF08508
PF08508: DUF1746
Fungal domain of unknown function (DUF1746)
- Curation status
- SEEDED
- Seed status
- UNKNOWN CANDIDATE
- Characterization
- UNSCORED
Grounding
PF08508: Fungal domain of unknown function (DUF1746)
IPR013715: integrated entry for Fungal domain of unknown function (DUF1746)
Source description
This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe, a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. The complex plays also an important role in the multivesicular body (MVB) pathway and functions in a post-endoplasmic reticulum pathway for protein degradation [InterPro reference PUB00075404]. This domain is also found in GLD1 from S. cerevisiae, also a component of the DSC E3 ubiquitin ligase complex involved in the targeting of the DSC complex to the Golgi apparatus and endosome membranes via the AP3 pathway to ubiquitinate Golgi/endosome membrane proteins [InterPro reference PUB00098082].
Evidence and references
- InterPro entry and its literature references. PUB identifiers are internal InterPro references, not PubMed identifiers. Unresolved citations link to the originating entry.
- Frozen description source: InterPro/Pfam API
Source descriptions and links are provenance, not independent functional validation.
Evidence counts: not scored.
Curated functional assertions
No curated functional assertions supplied.
Protein sequence examples
3 verified sequence examples. FASTA
| UniProt | Protein / organism | Sequence | Provenance |
|---|---|---|---|
| B0XYF7 | DSC E3 ubiquitin ligase complex subunit D Aspergillus fumigatus (strain CBS 144.89 / FGSC A1163 / CEA10) | 331 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| O14175 | DSC E3 ubiquitin ligase complex subunit 4 Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 281 aa; version 1 UniProt 2026_03 | UNIPROT FETCH1 sibling references |
| Q06104 | Golgi/endosome-localized DSC protein 1 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 294 aa; version 1 UniProt 2026_03 | UNIPROT FETCH |
Pfam membership is not functional evidence. Whole-protein sequences do not establish domain boundaries. A coverage gap here is not absence from UniProt.
Sequences and metadata: UniProt Consortium, CC BY 4.0.
Domain matches
No residue-level domain match evidence is available in this build. Structure and AlphaFold counters do not supply coordinates or establish function.
Snapshot counters
- proteins
- 1,326
- matches
- 1,353
- proteomes
- 1,282
- taxa
- 2,736
- structures
- 0
- alphafold models
- 1,116
- domain architectures
- 20
Classification basis
short name matches duf; name says unknown function; description says unknown function; domain of unknown function
No scoring reasons supplied.
Related Mech records
| Family | Mech | Record | Protein | Link basis |
|---|---|---|---|---|
| DUF1746 (PF08508) | ProteinTraitsMech | Dsc E3 ubiquitin ligase complex | Q06104 Golgi/endosome-localized DSC protein 1 | canonical example family classification |
| DUF1746 (PF08508) | ProteinTraitsMech | EGAD pathway | Q06104 Golgi/endosome-localized DSC protein 1 | canonical example family classification |
| DUF1746 (PF08508) | ProteinTraitsMech | Domain of unknown function DUF1746 | Q06104 Golgi/endosome-localized DSC protein 1 | canonical example family classification |
| DUF1746 (PF08508) | ProteinTraitsMech | Domain of unknown function DUF1746 | trait identifier | |
| DUF1746 (PF08508) | ProteinTraitsMech | Fungal domain of unknown function (DUF1746) | B0XYF7 DSC E3 ubiquitin ligase complex subunit D | canonical example family classification |
| DUF1746 (PF08508) | ProteinTraitsMech | Fungal domain of unknown function (DUF1746) | O14175 DSC E3 ubiquitin ligase complex subunit 4 | canonical example family classification |
| DUF1746 (PF08508) | ProteinTraitsMech | Fungal domain of unknown function (DUF1746) | Q06104 Golgi/endosome-localized DSC protein 1 | canonical example family classification |
| DUF1746 (PF08508) | ProteinTraitsMech | Fungal domain of unknown function (DUF1746) | trait identifier |
Curation history and reviews
No retained curation events supplied.
No retained review supplied.
Record source
Status and evidence
- Seed status
- A name-based classification of frozen InterPro/Pfam metadata. UNKNOWN CANDIDATE means the metadata explicitly says the function is unknown. KNOWN HISTORICAL DUF means a DUF name matched without that wording; this heuristic is not proof of a known function and does not establish experimental characterization. EX DUF means Pfam renamed the family away from a DUF/UPF name, as recorded in Pfam's previous identifiers; a rename usually follows published work on some members but is naming history, not proof of function for every member. Some EX DUF families' current names or descriptions still say the function is unknown; their classification basis lists this, and scoring does not treat them as characterized. FALSE POSITIVE TEXT HIT means the naming rules did not match.
- Characterization
- A separate evidence-scoring result. UNSCORED means no score has been calculated; it is not evidence that the family lacks a known function. Missing scores are not negative evidence. PARTIALLY CHARACTERIZED has partial support; KNOWN HISTORICAL DUF can inherit the seed label or reflect a known-function signal. Neither label implies experimental validation.
- Evidence counts
- Source-specific signals, not unique proteins, publications, or confidence scores. Known counts Rhea reactions and experimentally supported GO molecular-function annotations. Partial counts functional/domain assignments. Context counts structural, environmental, orthology, interaction and neighborhood signals; context alone does not assign function. Repeated annotations may not be independent.
- Curation status
- Reported separately from seed classification and characterization. SNAPSHOT ONLY means no curated metadata was supplied for this build. SEEDED denotes a source-derived record, not an expert-reviewed functional claim.
- Missing counts
- Not available means the source did not supply that counter. A zero is a reported count. Not scored means evidence counts are unavailable.