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biosafety level 2

METPO:1001103 · CLASS · REVIEWED

A biosafety level that poses moderate risk and is associated with human diseases present in the community.

BSL-2 moderate-hazard classification

DOI-backed graph linking moderate pathogen virulence and the presence of effective countermeasures to BSL-2 classification.

BSL-2 moderate-hazard classification Interactive directed graph showing evidence-backed causal relationships for biosafety level 2.

Edge evidence

  • moderate pathogen hazard produces biosafety level 2 METPO:2000202

    Moderate pathogen hazard with available countermeasures yields BSL-2 classification.

    • DOI:10.1146/annurev.micro.62.081307.162938 virulence factors Supports moderate virulence with treatability as the basis of BSL-2 classification.
  • biosafety level 2 is a biosafety level rdfs:subClassOf

    BSL-2 is a member of the biosafety-level classification.

    • DOI:10.1146/annurev.micro.62.081307.162938 virulence factors Supports BSL-2 as a member of the biosafety-level classification.
  • risk group 2 pathogen supports assignment to biosafety level 2

    RG2 agents (moderate individual, limited community risk) are assigned to BSL-2 containment.

    • DOI:10.1016/j.pathol.2020.09.006 Risk Group 2 ("moderate individual risk, limited community risk") associates RG-2 agents with BSL-2/PC-2.
  • pathogenicity influences selection of biosafety level 2

    Agent pathogenicity is a criterion driving risk-group/biosafety-level assignment.

    • DOI:10.1016/j.pathol.2020.09.006 Risk Groups are assigned based on pathogenicity, transmission, host range, and countermeasure availability.
  • mode and ease of transmission influences selection of biosafety level 2

    Mode and ease of transmission is a criterion driving biosafety-level assignment; airborne transmission escalates above BSL-2.

    • DOI:10.1016/j.pathol.2020.09.006 Risk Groups assigned based on mode/ease of transmission; airborne lethal agents are escalated to BSL-3.
  • aerosol- or splash-generating procedure necessitates use of biological safety cabinet class I/II

    Procedures generating infectious aerosols or splashes require a class I/II biological safety cabinet at BSL-2.

    • DOI:10.1007/978-1-4939-8935-5_19 All procedures that could create infectious aerosols/splashes are conducted in biological safety cabinets at BSL-2.
  • appropriate personal protective equipment mitigates risk in biosafety level 2

    Lab coats, gloves, and eye protection reduce exposure risk at BSL-2.

    • DOI:10.1016/j.pathol.2020.09.006 Appropriate PPE (lab coats and gloves), with eye protection as needed, must be worn in BSL-2/PC-2.
  • restricted laboratory access is required for biosafety level 2

    Restricted laboratory access is a required administrative control at BSL-2.

    • DOI:10.1007/978-1-4939-8935-5_19 BSL-2 requires restricted access and additional agent-specific training compared with BSL-1.

Knowledge gaps & discussions (1)

KNOWLEDGE_GAP OPEN Knowledge gap for biosafety level 2: Background : Untargeted microbiome modulation has achieved conflicting results in post-infectious irritable bowel syndrome (PI-IBS).

Surfaced by the Europe PMC literature gap-signal scan (categories: controversy_conflict, future_work, limitations_barriers, unclear_unknown). Curator review required: set attaches_to, refine the prompt, and weigh the cited evidence.

4 evidence item(s)
NO_EVIDENCE PMID:41683313 Background : Untargeted microbiome modulation has achieved conflicting results in post-infectious irritable bowel syndrome (PI-IBS). Gap-signal sentence (controversy_conflict) from the cited abstract.
NO_EVIDENCE PMID:41413233 Recently, the gut microbiota (GM) has gained attention for its potential involvement in blood pressure regulation; however, polyamine metabolism involvement remains poorly understood. Gap-signal sentence (unclear_unknown) from the cited abstract.
NO_EVIDENCE PMID:41640410 However, their clinical translation is hampered by challenges within the harsh gastrointestinal milieu, including low viability, poor colonization, and insufficient target specificity. Gap-signal sentence (limitations_barriers) from the cited abstract.
NO_EVIDENCE PMID:41490313 However, how these core strains interact with each other and with other gut microbes is largely unknown. Gap-signal sentence (unclear_unknown) from the cited abstract.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.1146/annurev.micro.62.081307.162938

Parent traits (1)

Synonyms (1)

  • 2 RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1001103 [+47.740, -114.909, +42.074, +68.627, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_CAUSAL_GRAPH · claude

    Added DOI-backed causal graph linking moderate pathogen hazard to BSL-2 classification.

  3. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000202×1, rdfs:subClassOf×1).

  4. · ENRICH_CAUSAL_GRAPH · claude

    Added 6 evidence-backed generic edges (7 new nodes) from the deep-research report.