oval shaped

Edge evidence

• PBP2b enables peripheral peptidoglycan synthesis RO:0002327

  PBP2b supports peripheral peptidoglycan synthesis in ovococcal elongation.

  • DOI:10.1089/mdr.2014.0032 PBP2b of ovococci Supports PBP2b as a key ovococcal elongation factor.
• MapZ/FtsZ division-positioning system positions septal peptidoglycan synthesis

  MapZ/FtsZ positioning organizes the division-associated wall synthesis zone.

  • DOI:10.1016/j.mib.2016.07.014 relies on the membrane protein MapZ Supports MapZ/FtsZ involvement in S. pneumoniae cell division.
• peripheral peptidoglycan synthesis combines with septal peptidoglycan synthesis

  Peripheral and septal synthesis together generate the ovococcal growth pattern.

  • DOI:10.1016/j.cub.2021.04.041 dynamics of peptidoglycan assembly Supports nanometer-scale PG synthesis dynamics in ovoid bacteria.
• septal peptidoglycan synthesis causes ellipsoidal geometry biolink:causes

  Coordinated septal and peripheral synthesis shapes an ellipsoidal cell body.

  • DOI:10.1089/mdr.2014.0032 ovococci that are ellipsoid Supports the ellipsoidal ovococcal morphology endpoint.
• ellipsoidal geometry manifests as oval shaped METPO:2007400

  Rounded ellipsoidal geometry manifests the oval-shaped trait.

  • DOI:10.1089/mdr.2014.0032 ellipsoid Supports oval shape as an ellipsoidal bacterial morphology.
• peripheral peptidoglycan synthesis positively influences oval shaped

  Peripheral PG synthesis extends the cell prior to septal synthesis, producing elongated ovoid geometry.

  • DOI:10.1128/spectrum.04750-22 Ovococcal division model: "the cell synthesizes peripheral PG alone for a short time to extend the cell before septal PG synthesis is initiated".
• MreC positively influences oval shaped

  Loss of mreC yields smaller, more spherical cells, indicating MreC promotes elongated ovoid shape.

  • DOI:10.1038/s41467-023-38904-9 "cells lacking mreC, pbp2B, and rodA appeared smaller and more spherical" - MreC supports ovoid elongation.
• RodA positively influences oval shaped

  Loss of rodA yields smaller, more spherical cells, indicating RodA promotes elongated ovoid shape.

  • DOI:10.1038/s41467-023-38904-9 "cells lacking mreC, pbp2B, and rodA appeared smaller and more spherical" - RodA supports ovoid elongation.
• PBP2b positively influences oval shaped

  Loss of pbp2B yields smaller, more spherical cells, indicating PBP2b promotes elongated ovoid shape.

  • DOI:10.1038/s41467-023-38904-9 "cells lacking mreC, pbp2B, and rodA appeared smaller and more spherical" - PBP2b supports ovoid elongation.
• RodA part of Rod complex (elongasome) peptidoglycan synthesis biolink:part_of

  RodA together with MreC and PBP2b forms the Rod complex driving peripheral elongation PG synthesis.

  • DOI:10.1038/s41467-023-38904-9 mreC, pbp2B, and rodA act together in the elongation machinery whose loss makes cells spherical.
• MapZ/FtsZ division-positioning system positively regulates correct septum placement / division-site marking

  MapZ/LocZ mark division sites and ensure correct septum placement.

  • DOI:10.1042/bsr20221664 "MapZ and LocZ are reported as proteins that mark division sites and ensure correct septum placement, respectively".