facultatively anaerobic

Edge evidence

• molecular oxygen enables aerobic respiration RO:0002327

  In facultative anaerobes, oxygen availability permits aerobic respiration.

  • DOI:10.1111/cmi.13338 cope with changing oxygen levels Review frames facultative anaerobe fitness around changing oxygen availability; exact pathways vary by organism.
• molecular oxygen regulates FNR oxygen-responsive regulator RO:0002211

  FNR senses oxygen status and changes respiratory gene expression.

  • DOI:10.1007/BF00445650 molecular oxygen is an important regulatory signal Review describes oxygen-dependent regulation by FNR.
• FNR oxygen-responsive regulator activates in absence of oxygen anaerobic respiration

  FNR activates anaerobic respiratory gene expression under anoxic conditions.

  • DOI:10.1007/BF00445650 activates transcription in the absence of O2 Supports FNR activation of anaerobic respiration genes without oxygen.
• facultatively anaerobic has alternative process anaerobic respiration

  Facultative anaerobiosis includes the capacity to grow using anaerobic respiration when oxygen is absent.

  • DOI:10.1007/BF00445650 expression of anaerobic respiration E. coli-focused evidence for anaerobic respiratory programs in a facultative anaerobe.
• molecular oxygen oxidizes/inactivates FNR oxygen-responsive regulator

  Oxygen oxidizes the FNR [4Fe-4S] cluster, inactivating FNR and preventing transcription of anaerobic respiration genes.

  • DOI:10.1101/2025.01.08.631794 In the presence of oxygen, FNR is inactivated through oxidation of its FeS cluster, preventing transcription of anaerobic respiration genes.
• ArcA/ArcAB two-component regulator represses aerobic respiration

  ArcAB represses the aerobic respiration program, mediating metabolic adaptation to lower oxygen.

  • DOI:10.1128/mbio.01448-23 ArcAB, a two-component regulatory system that represses aerobic respiration, is a key mediator of metabolic adaptation.
• alternative terminal electron acceptors enable anaerobic electron transport chain operation

  Alternative terminal electron acceptors enable anaerobic electron transport chain operation when oxygen is absent.

  • DOI:10.1038/s41467-024-51029-x Alternative terminal electron acceptors (nitrate, fumarate, DMSO, TMAO) allow anaerobic ETC operation when O2 is absent.
• anaerobic electron transport chain operation is part of anaerobic respiration

  Anaerobic ETC operation constitutes the respiratory energy metabolism used in the absence of oxygen.

  • DOI:10.1038/s41467-024-51029-x Anaerobic ETC operation with alternative terminal electron acceptors underlies anaerobic respiration in facultative anaerobes.