oxygen preference

METPO:1000601 · CLASS · REVIEWED

A phenotype that is relating to an organism's oxygen requirements or tolerance for growth.

Oxygen-preference O2-availability axis

DOI-backed graph linking ambient molecular-oxygen availability to the four child oxygen-preference phenotypes (aerobic, anaerobic, microaerophilic, facultative) that classify how organisms use or tolerate O2.

Oxygen-preference O2-availability axis Interactive directed graph showing evidence-backed causal relationships for oxygen preference.

Edge evidence

  • ambient molecular oxygen defines oxygen preference METPO:2007500

    Ambient molecular-oxygen concentration is the quantitative axis defining oxygen-preference phenotypes.

    • DOI:10.3389/fmicb.2014.00674 various capacities in their utilization of molecular oxygen Supports molecular oxygen utilization as the classification axis for oxygen-preference phenotypes.
  • aerobic is a oxygen preference rdfs:subClassOf

    Aerobic is a child oxygen-preference phenotype.

    • DOI:10.3389/fmicb.2014.00674 aerobic ... respiration capacities Supports aerobic as an oxygen-use phenotype within oxygen-preference classification.
  • anaerobic is a oxygen preference rdfs:subClassOf

    Anaerobic is a child oxygen-preference phenotype.

    • DOI:10.3389/fmicb.2014.00674 aerobic, microaerobic, and anaerobic reductases Supports anaerobic as a distinct oxygen-preference classification.
  • microaerophilic is a oxygen preference rdfs:subClassOf

    Microaerophilic is a child oxygen-preference phenotype.

    • DOI:10.3389/fmicb.2014.00674 aerophilic, microaerophilic, or anaerobic Supports microaerophilic as a low-O2 setting on the oxygen-preference axis.
  • facultative oxygen preference is a oxygen preference rdfs:subClassOf

    Facultative oxygen preference is a child oxygen-preference phenotype.

    • DOI:10.1111/cmi.13338 cope with changing oxygen levels Supports facultative organisms as a mixed-O2 setting on the oxygen-preference axis, switching between aerobic and anaerobic metabolism.
  • O2 as terminal electron acceptor enables aerobic RO:0002327

    Obligate aerobic growth depends on molecular oxygen as terminal electron acceptor.

    • DOI:10.1371/journal.ppat.1012084 Obligate aerobes use only oxygen as the terminal electron acceptor, defining aerobic oxygen-preference.
  • molecular oxygen serves as O2 as terminal electron acceptor

    Molecular oxygen functions as the terminal electron acceptor in aerobic respiration.

    • DOI:10.1371/journal.ppat.1012084 Oxygen is used as the terminal electron acceptor of the aerobic respiratory chain.
  • oxygen / reactive oxygen species stress upregulates detoxifying-enzyme gene expression

    O2 or H2O2 stress upregulates detoxifying-enzyme genes.

    • DOI:10.1128/aem.00606-23 Expression of genes encoding detoxifying enzymes was upregulated in response to O2 or H2O2 stress.
  • detoxifying-enzyme gene expression increases oxygen tolerance RO:0002213

    A larger detoxifying-enzyme repertoire increases survival under oxygen exposure.

    • DOI:10.1128/aem.00606-23 Cells with more detoxifying genes survived longer than those with few scavenging enzymes.
  • catalase degrades hydrogen peroxide METPO:2000007

    Catalase rapidly degrades hydrogen peroxide, a reactive oxygen species.

    • DOI:10.1038/s43705-023-00251-7 Catalase is the most prominent enzyme for H2O2 degradation at higher concentrations.
  • superoxide dismutase increases oxygen tolerance RO:0002213

    Higher superoxide dismutase activity is associated with higher oxygen tolerance.

    • DOI:10.1038/s43705-023-00251-7 Higher Sod activity corresponded to higher oxygen tolerance.

Provenance

Source
METPO (2025-11-25)
Definition source
PMID:21413255

Parent traits (1)

Synonyms (2)

  • Physiology and metabolism.oxygen tolerance.oxygen tolerance RELATED_SYNONYM · metpo.owl
  • metabolism RELATED_SYNONYM · metpo.owl

kg-microbe context

Matched 1 kg-microbe node via direct_metpo.

  • METPO:1000601 [-1.145, -2.522, -2.827, -0.321, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · CURATED_CAUSAL_GRAPH · claude

    Added DOI-backed causal graph framing oxygen preference as the O2-availability axis with child aerobic, anaerobic, microaerophilic, and facultative phenotypes.

  3. · IMPROVED_CAUSAL_GRAPH_EVIDENCE · codex

    Replaced PMID fallback CausalEdge references with DOI-backed oxygen-utilization and facultative oxygen-response citations.

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 4 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (rdfs:subClassOf×4).

  5. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2007500×1).

  6. · ENRICH_CAUSAL_GRAPH · claude

    Added 6 evidence-backed generic edges (8 new nodes) from the deep-research report.

  7. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 3 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (RO:0002213×2, RO:0002327×1).

  8. · GROUND_CAUSAL_NODES · claude

    Grounded 3 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:15379×1, UniProtKB:A0A071MK53×1, UniProtKB:A0A009QPW9×1).

  9. · GROUND_CAUSAL_NODES · claude

    Grounded 1 causal-node grounding field(s) via mappings/node_grounding.tsv (CHEBI:16240×1).

  10. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 1 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (METPO:2000007×1).