pressure optimum

Edge evidence

• hydrostatic pressure defines pressure optimum METPO:2007500

  The hydrostatic-pressure axis defines the value at which growth is fastest.

  • DOI:10.3389/fmolb.2022.1058381 Pressure-adaptation review supports an organism-specific optimal growth pressure as the defining piezophile quantity.
• pressure optimum associated with maximal growth rate biolink:associated_with

  The optimum pressure marks the peak of the pressure-versus-growth curve.

  • DOI:10.1099/ijsem.0.001671 Colwellia marinimaniae MTCD1 illustrates a measurable pressure optimum (120 MPa).
• membrane unsaturated fatty acids enables pressure optimum RO:0002327

  Increased membrane unsaturated/PUFA content enables growth at elevated hydrostatic pressure, shaping the pressure optimum.

  • DOI:10.3389/fmolb.2022.1058381 Review: abundance of membrane lipids with unsaturated and branched-chain fatty acids rises with increasing HHP.
• intracellular cation concentration increases intracellular osmotic pressure RO:0002213

  Increased cation import raises intracellular osmotic pressure.

  • DOI:10.1128/mbio.00958-23 Authors propose increased cation import to raise intracellular osmotic pressure under HHP.
• intracellular osmotic pressure enables high hydrostatic pressure tolerance RO:0002327

  Elevated intracellular osmotic pressure enables high hydrostatic pressure tolerance.

  • DOI:10.1128/mbio.00958-23 Proposed HHP-tolerance model: importing cations to raise intracellular osmotic pressure.
• compatible solute accumulation promotes protein stabilization by preferential hydration RO:0002213

  Compatible solutes (piezolytes) stabilize proteins by preferential hydration.

  • DOI:10.3390/microorganisms11071629 Compatible solutes displace water bound to proteins via preferential hydration; glutamate/betaine/beta-hydroxybutyrate detected at 20-30 MPa.
• compatible solute accumulation enables high hydrostatic pressure tolerance RO:0002327

  Compatible-solute (piezolyte) accumulation enables pressure tolerance.

  • DOI:10.1007/s00253-023-12906-5 Osmolyte-based protection (proline, glutamate, betaine, beta-hydroxybutyrate, TMAO) supports pressure tolerance across taxa.