desiccation tolerant

Edge evidence

• extreme water loss causes anhydrobiotic state biolink:causes

  Extreme dehydration triggers entry into the anhydrobiotic state.

  • DOI:10.3390/microorganisms10020432 Anhydrobiosis review describes entry into a reversible metabolism-off state upon water loss.
• anhydrobiotic state enables desiccation tolerant RO:0002327

  Reversible anhydrobiosis is the basis of desiccation survival.

  • DOI:10.3390/microorganisms10020432 Anhydrobiosis enables reversible survival of near-complete water loss.
• double-strand break repair enables desiccation tolerant RO:0002327

  Efficient DNA double-strand-break repair restores integrity on rehydration.

  • DOI:10.3390/genes14091803 Deinococcus radiodurans shares DNA-repair machinery between radiation and desiccation tolerance.
• extreme water loss causes oxidative stress / ROS biolink:causes

  Drying below the protective water monolayer threshold induces oxidative stress / ROS.

  • DOI:10.1021/acs.chemrev.2c00659 Cross-kingdom review: desiccation tolerance organisms face oxidative stress and recover after rehydration.
• trehalose stabilizes plasma membrane

  Trehalose interacts with phospholipid polar head groups to stabilize membranes during dehydration.

  • DOI:10.1007/s00203-023-03683-w Trehalose interacts with phospholipid polar groups to stabilize membranes.
• trehalose promotes vitrification / glass formation RO:0002213

  Trehalose-mediated vitrification reduces molecular motion and prevents crystallization in the dry state.

  • DOI:10.1038/s41598-023-31586-9 Trehalose-mediated vitrification reduces molecular motion and prevents crystallization.
• superoxide dismutase activity negatively regulates oxidative stress / ROS

  Superoxide dismutase is upregulated as a conserved antioxidant defense, lowering ROS.

  • DOI:10.1021/acs.chemrev.2c00659 Desiccation-tolerant organisms upregulate superoxide dismutase as conserved oxidative-stress defense.
• catalase activity negatively regulates oxidative stress / ROS

  Catalase detoxifies H2O2/ROS as a conserved oxidative-stress defense during drying.

  • DOI:10.1021/acs.chemrev.2c00659 Desiccation-tolerant organisms upregulate catalases for ROS detoxification.
• heat shock protein / chaperone activity negatively regulates protein aggregation

  Heat shock proteins bind denatured proteins, preventing aggregation and aiding repair on rehydration.

  • DOI:10.1007/s00203-023-03683-w Heat shock proteins bind denatured proteins, preventing aggregation and aiding repair on rehydration.
• desiccation-related intrinsically disordered proteins synergizes with trehalose

  Desiccation-related IDPs synergize with endogenous cosolutes such as trehalose to enhance protection during drying.

  • DOI:10.7554/eLife.97231 Desiccation-related IDPs synergize with endogenous cosolutes to enhance protection during drying.