cadmium tolerant

Edge evidence

• cadmium(2+) ion challenges cadmium tolerant METPO:2007406

  Cytoplasmic cadmium is the toxic challenge the trait counters.

  • DOI:10.3389/fmicb.2020.00047 Cupriavidus metallidurans BS1 tolerates Cd(2+) to a MIC of 2.5 mM.
• czc cation-efflux system enables cadmium ion transmembrane transport RO:0002327

  CzcP exports cadmium together with zinc and cobalt cations.

  • DOI:10.1111/j.1365-2958.2009.06792.x CzcP exports transition metals Zn(2+), Cd(2+), and Co(2+).
• cadmium ion transmembrane transport mitigates cadmium(2+) ion METPO:2007407

  Czc-mediated export depletes the cytoplasmic cadmium pool.

  • DOI:10.1111/j.1365-2958.2009.06792.x The czc efflux system of C. metallidurans confers cadmium resistance.
• metallothionein / thiol-rich metal-binding proteins enables cadmium ion sequestration RO:0002327

  Thiol-rich metallothioneins bind and sequester cytoplasmic Cd(2+).

  • DOI:10.1007/s40201-023-00887-6 Metallothioneins bind Cd(II); thiol-rich proteins mediate cadmium sequestration as a microbial resistance mechanism.
• cadmium ion sequestration mitigates cadmium(2+) ion METPO:2007407

  Sequestration of cadmium lowers the free toxic cytoplasmic Cd(2+) pool.

  • DOI:10.1007/s40201-023-00887-6 Metallothionein/thiol-rich sequestration removes free cytoplasmic Cd(II) as a detoxification mechanism.
• CadA P-type (P1B) ATPase enables cadmium ion transmembrane transport RO:0002327

  CadA P1B-type ATPase uses ATP to pump Cd(II) from cytoplasm to periplasm.

  • DOI:10.1007/s40201-023-00887-6 P-type (P1B) ATPases (CadA) use ATP to pump Cd(II) from cytoplasm to periplasm.
• zinc(2+) ion induces czc cation-efflux system

  Zinc cross-induces expression of the czc cation-efflux cadmium-resistance program.

  • DOI:10.1007/s40201-023-00887-6 czc expression is induced by zinc; zinc exposure enhances cadmium resistance via the efflux program.