coagulase activity

METPO:1007089 · CLASS · SEEDED

A physiological enzyme-activity phenotype in which a cell produces coagulase factors that activate prothrombin and convert fibrinogen to fibrin, clotting blood plasma.

Trait evidence (2)

DOI:10.1159/000333447
Clinical isolates of Staphylococcus aureus secrete coagulases, polypeptides that bind to and activate prothrombin

McAdow, Missiakas and Schneewind review how staphylococcal coagulases activate prothrombin, convert fibrinogen to fibrin, and clot plasma or blood.
DOI:10.1371/journal.ppat.1001036
Coa and vWbp promote the non-proteolytic activation of prothrombin and cleavage of fibrinogen

Cheng et al. experimentally show that the two S. aureus coagulases, Coa and von Willebrand factor binding protein, mediate prothrombin and fibrinogen reactions relevant to staphylococcal clot formation.

Provenance

Identifier source: METPO (2026-06-12)
Author: Marcin Joachimiak
Definition source: DOI:10.1159/000333447

Parent traits (1)

phenotype METPO:1000059

Children (2)

Synonyms (2)

coagulase test EXACT_SYNONYM · metpo.owl
coagulase-positive RELATED_SYNONYM · DOI:10.1159/000333447

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Staphylococcus aureus NCBITaxon:1280 DOI:10.1371/journal.ppat.1001036 Canonical coagulase-positive bacterium that secretes Coa and vWbp.

Curation history

2026-09-11T00:00:00Z · SEEDED_FROM_METPO · codex
Added the active METPO coagulase activity class as a DOI-backed TraitRecord after a repository-wide duplicate review covering ignored and hidden files.