coagulase negative

METPO:1007091 · CLASS · SEEDED

Test-outcome phenotype where the coagulase test yields a negative result. The underlying enzyme-organism relation should additionally be asserted via <organism> METPO:2000303 'does not show activity of' <coagulase enzyme term> once a sufficiently specific enzyme term is selected.

Trait evidence (2)

DOI:10.3390/microorganisms9040830
Coagulase-negative staphylococci (CoNS) form a large group of Gram-positive cocci united by their mutual lack of the virulence factor coagulase

Michels et al. define coagulase-negative staphylococci by absence of the coagulase virulence factor, supporting the negative assay-outcome phenotype.
https://www.ncbi.nlm.nih.gov/books/NBK563240/
Staphylococcus epidermidis is a coagulase-negative, gram-positive cocci bacteria that form clusters

Lee and Anjum identify S. epidermidis as coagulase-negative, providing a stable species-level example of a negative coagulase test outcome.

Provenance

Identifier source: METPO (2026-06-12)
Author: Marcin Joachimiak
Definition source: DOI:10.3390/microorganisms9040830

Parent traits (1)

coagulase activity METPO:1007089

Synonyms (2)

coagulase - EXACT_SYNONYM · metpo.owl
coagulase test negative EXACT_SYNONYM · metpo.owl

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

Staphylococcus epidermidis NCBITaxon:1282 https://www.ncbi.nlm.nih.gov/books/NBK563240/ Lee and Anjum describe S. epidermidis as a coagulase-negative Staphylococcus species.

Curation history

2026-09-11T09:54:43Z · SEEDED_FROM_METPO · seed_from_metpo
imported from data/raw/metpo.owl (CLASS)
2026-09-11T09:59:00Z · ENRICHED_FROM_LITERATURE · codex
Enriched the seeded METPO coagulase negative test-outcome phenotype with DOI- and NCBI-backed evidence after a repository-wide duplicate review covering ignored and hidden files.