TraitMech

TraitMech › OTHER

coagulase positive

METPO:1007090 · CLASS · SEEDED

Test-outcome phenotype where the coagulase test yields a positive result (plasma clotting). The underlying enzyme-organism relation should additionally be asserted via <organism> METPO:2000302 'shows activity of' <coagulase enzyme term> once a sufficiently specific enzyme term is selected (no GO/EC term currently exists at the bacteriological coagulase test granularity).

Trait evidence (2)

  • DOI:10.1099/mic.0.000019
    coagulase-positive S. aureus bacteria promoted clotting of plasma which was not seen when a coagulase-deficient mutant strain was used

    Loof et al. show that coagulase-positive S. aureus clots plasma in a way lost from a coagulase-deficient mutant, directly supporting the positive test-outcome phenotype.

  • DOI:10.1371/journal.ppat.1001036
    Clinical isolates of the human pathogen Staphylococcus aureus secrete coagulase (Coa), a polypeptide that binds to and activates prothrombin

    Cheng et al. connect S. aureus Coa secretion to prothrombin activation, the clotting activity detected by the coagulase test.

Provenance

Identifier source
METPO (2026-06-12)
Author
Marcin Joachimiak
Definition source
DOI:10.1099/mic.0.000019

Parent traits (1)

Synonyms (2)

  • coagulase + EXACT_SYNONYM · metpo.owl
  • coagulase test positive EXACT_SYNONYM · metpo.owl

kg-microbe context

No kg-microbe node embedding matched this record in the 2026-04-25 deepwalk.

Canonical examples (1)

Organisms cited as exemplars of this trait. Taxon ids are NCBITaxon and link out to the NCBI record.

  • Staphylococcus aureus NCBITaxon:1280 DOI:10.1099/mic.0.000019 Loof et al. use coagulase-positive S. aureus as a direct plasma-clotting example and contrast it with a coagulase-deficient mutant.

Curation history

  1. · SEEDED_FROM_METPO · seed_from_metpo

    imported from data/raw/metpo.owl (CLASS)

  2. · ENRICHED_FROM_LITERATURE · codex

    Enriched the seeded METPO coagulase positive test-outcome phenotype with DOI-backed plasma-clotting evidence after a repository-wide duplicate review covering ignored and hidden files.