metal tolerant

Edge evidence

• toxic heavy-metal ion challenges metal tolerant METPO:2007406

  Elevated heavy-metal concentrations are the environmental challenge the trait counters.

  • DOI:10.3389/fmicb.2020.00047 Cupriavidus metallidurans encodes many metal-resistance determinants confronting multiple toxic metals.
• metal efflux pump enables metal ion transmembrane export RO:0002327

  CBA pumps, P-type ATPases, and CDFs export toxic metal cations from the cytoplasm.

  • PMID:12829273 Nies reviews efflux-mediated heavy-metal resistance as the dominant prokaryotic tolerance mechanism.
• metal ion transmembrane export enables metal tolerant RO:0002327

  Cytoplasmic detoxification by export realizes the metal-tolerant phenotype.

  • PMID:12829273 Nies frames efflux-based export as the basis of broad heavy-metal tolerance.
• ArsC arsenate reductase converts arsenate As(V)

  ArsC arsenate reductase reduces As(V) to As(III) as the first detoxification step.

  • DOI:10.52700/jmmg.v5i1.155 Review: "ArsC converting As(V) to As(III) followed by extrusion"; general across bacteria.
• arsenate As(V) is converted to arsenite As(III)

  Arsenate is reduced to arsenite, the species handled by efflux pumps.

  • DOI:10.52700/jmmg.v5i1.155 Review: ArsC converts As(V) to As(III) followed by extrusion.
• ars operon enables arsenic tolerance RO:0002327

  The arsC + arsB/acr3 ars operon mediates arsenate reduction and arsenite extrusion conferring arsenic tolerance.

  • DOI:10.7717/peerj.18383 "a cooperative mechanism involving detoxification through arsenate reduction" via arsC/arsA/arsB/acr3 genes across mixed soil taxa.
• arsenic tolerance is a metal tolerant rdfs:subClassOf

  Arsenic (metalloid) tolerance is a component of the broad metal-tolerant phenotype.

  • DOI:10.52700/jmmg.v5i1.155 Arsenic detoxification (reduction + efflux) is part of generic bacterial heavy-metal/metalloid resistance.
• metal efflux pump mediates metal tolerant

  P-type ATPase, CDF, and RND efflux transporters mediate heavy-metal resistance in most bacteria.

  • DOI:10.52700/jmmg.v5i1.155 "resistance in most bacteria is mediated by P-type ATPase efflux, diffusion facilitator transporters of cations and RND" - generic review.