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ionizing radiation tolerant

traitmech:000008 · CLASS · REVIEWED

An environmental tolerance in which an organism survives high doses of ionizing radiation (e.g. gamma rays), typically via efficient repair of DNA double-strand breaks and protection of the proteome from oxidative damage.

Ionizing-radiation tolerance via double-strand-break repair

Evidence-backed causal sketch linking gamma-radiation exposure to efficient repair of DNA double-strand breaks and Mn-mediated oxidative protection.

Ionizing-radiation tolerance via double-strand-break repair Interactive directed graph showing evidence-backed causal relationships for ionizing radiation tolerant.

Edge evidence

  • gamma radiation challenges ionizing radiation tolerant METPO:2007406

    Gamma exposure is the environmental challenge the trait counters.

    • DOI:10.3390/genes14091803 Deinococcus radiodurans tolerates gamma D10 doses exceeding 12 kGy.
  • double-strand break repair enables ionizing radiation tolerant RO:0002327

    Efficient DSB repair restores chromosomal integrity after ionizing-radiation damage.

    • DOI:10.3390/genes14091803 D. radiodurans tolerates lethal gamma doses through DSB-repair machinery.
  • manganese-mediated oxidative-damage protection enables ionizing radiation tolerant RO:0002327

    Mn-antioxidant proteome protection preserves repair capacity under irradiation.

    • DOI:10.1101/cshperspect.a012765 Intracellular Mn/Fe ratio correlates with bacterial radiation resistance.
  • gamma radiation causes DNA double-strand breaks and clustered lesions biolink:causes

    Ionizing radiation produces DNA double- and single-strand breaks and complex clustered lesions.

    • DOI:10.1007/978-3-031-18810-7_9 Ionizing radiation produces single- and double-strand DNA breaks, abasic sites and complex clustered lesions (broad radiobiology, across taxa).
  • double-strand break repair repairs DNA double-strand breaks and clustered lesions

    Double-strand break repair resolves the clustered DNA lesions inflicted by ionizing radiation.

    • DOI:10.1007/978-3-031-18810-7_9 DSB-repair machinery resolves radiation-induced strand breaks and clustered lesions to restore chromosomal integrity.
  • high intracellular Mn/Fe ratio positively correlates with ionizing radiation tolerant

    A high intracellular Mn/Fe ratio correlates with antioxidant proteome protection and survival of ionizing radiation.

    • DOI:10.1101/cshperspect.a012765 Strong correlation: radiation-resistant bacteria carry more Mn2+ and ~3x less Fe2+, giving antioxidant protection of the cellular proteome.
  • high intracellular Mn/Fe ratio enables manganese-mediated oxidative-damage protection RO:0002327

    A high Mn/Fe ratio supplies the Mn(II) complexes that shield repair proteins from oxidative damage.

    • DOI:10.1101/cshperspect.a012765 Elevated Mn/Fe ratio underlies Mn-antioxidant protection of the proteome during irradiation.

Provenance

Source
METPO (2025-11-25)
Definition source
DOI:10.3390/genes14091803

Parent traits (1)

Synonyms (1)

  • gamma radiation resistant NARROW_SYNONYM · DOI:10.3390/genes14091803

kg-microbe context

Matched 1 kg-microbe node via parent_proxy.

  • METPO:1000059 [-2.682, -2.070, -3.656, -0.652, …]

512-dim DeepWalkSkipGramEnsmallen embedding from kg-microbe (2026-04-25).

Nearest neighbors in embedding space

Top-8 cosine-similar METPO traits from the 2026-04-25 deepwalk (512-D).

Curation history

  1. · PROPOSED_FROM_RESEARCH · claude

    Proposed candidate ENVIRONMENT trait (ionizing/gamma radiation tolerance) from literature research; sub-variant of radiotolerant.

  2. · CURATED_CAUSAL_GRAPH · claude

    Added evidence-backed causal graph (DSB repair + Mn-antioxidant) with GO node grounding and RO/METPO predicate groundings; promoted PROPOSED to REVIEWED.

  3. · ENRICH_CAUSAL_GRAPH · claude

    Added 4 evidence-backed generic edges (2 new nodes) from the deep-research report.

  4. · GROUND_CAUSAL_PREDICATES · claude

    Grounded 2 causal-edge predicate_id field(s) via mappings/predicate_grounding.tsv (biolink:causes×1, RO:0002327×1).