quorum sensing

Edge evidence

• autoinducer participates in quorum sensing biolink:participates_in

  Autoinducer accumulation drives quorum sensing.

  • DOI:10.1146/annurev.cellbio.21.012704.131001 Waters & Bassler review autoinducer-mediated communication.
• quorum sensing enables quorum sensing RO:0002327

  The sensing process realizes the quorum-sensing trait.

  • DOI:10.1146/annurev.micro.55.1.165 Miller & Bassler review quorum-sensing regulatory logic.
• threshold autoinducer concentration enables detection by cognate signal receptor

  Once autoinducer reaches a threshold concentration it is detected by cognate sensor proteins, activating QS.

  • DOI:10.3390/ijms25052655 Once the concentration of secreted AI molecules has reached a threshold level, they are detected by cognate sensor proteins (generic, cross-taxa).
• cognate signal receptor positively regulates autoinducer

  Activated signal-receptor complex promotes autoinducer synthase transcription, forming the autoinduction positive-feedback loop.

  • DOI:10.3390/ijms25052655 AHL-LuxR complex recognises the lux box of luxI to promote luxI transcription, described as a positive feedback loop central to autoinduction.
• quorum-quenching enzyme inactivates autoinducer

  Quorum-quenching enzymes degrade/inactivate QS autoinducer signals, interrupting quorum sensing.

  • DOI:10.3390/ijms25052655 QQ enzymes that inactivate QS signals (broad inhibitory branch).
• quorum-sensing inhibitor inhibits cognate signal receptor RO:0002212

  QS inhibitors chemically disrupt quorum sensing by inhibiting signal receptors / QS pathways.

  • DOI:10.3390/ijms25052655 QS inhibitors (QSIs) that chemically disrupt QS via inhibition of signal receptors (broad class).