facultatively aerobic

Edge evidence

• molecular oxygen enables aerobic respiration RO:0002327

  Facultatively aerobic organisms can use oxygen-dependent respiration when oxygen is available.

  • DOI:10.1016/j.celrep.2023.112444 terminal oxidases transfer electrons from the ETC to O2 Supports aerobic respiration through oxygen-reducing terminal oxidases.
• facultatively aerobic has alternative process anaerobic metabolism

  Facultative aerobic growth retains a growth mode when oxygen is absent.

  • DOI:10.1089/ars.2011.4051 utilizing other substrates as final electron acceptors Review describes respiratory adaptation to oxygen shortage using alternative electron acceptors.
• molecular oxygen regulates FNR-type oxygen-responsive regulation RO:0002211

  Oxygen-responsive regulators tune metabolism across oxic and anoxic conditions.

  • DOI:10.1089/ars.2011.4051 Fnr-type transcriptional regulators that directly sense O2 Supports oxygen sensing by FNR-type regulators.
• FNR-type oxygen-responsive regulation regulates switch between aerobic respiration

  Oxygen-sensing regulation helps switch respiratory metabolism as oxygen availability changes.

  • DOI:10.1089/ars.2011.4051 adaptation of respiratory metabolism to changing environments Supports regulatory switching between oxygen regimes.
• terminal electron acceptor availability determines terminal respiratory branch choice

  Which terminal respiratory enzyme is active depends on the available final electron acceptor.

  • DOI:10.1128/jb.00389-22 which terminal enzyme is active depends on the availability of the final electron acceptor: fumarate or oxygen.
• ArcAB two-component system represses aerobic respiration

  ArcAB two-component regulatory system represses aerobic respiration under reducing conditions.

  • DOI:10.1128/mbio.01448-23 ArcAB, a two-component regulatory system that represses aerobic respiration; conserved switch in Enterobacterales.
• molecular oxygen inactivates FNR-type oxygen-responsive regulation

  Oxygen directly inactivates FNR by oxidizing its iron-sulfur cluster, a core oxygen-sensing mechanism.

  • DOI:10.1093/nar/gkad750 oxygen directly inactivates Fnr by oxidizing that iron-sulfur cluster; widely generalizable oxygen-sensing edge.
• FNR-type oxygen-responsive regulation activates anaerobic metabolism genes RO:0002213

  When active under anoxia, FNR activates anaerobic metabolism genes.

  • DOI:10.1093/nar/gkad750 when active, Fnr activates anaerobic metabolism genes and represses aerobic genes.
• FNR-type oxygen-responsive regulation represses aerobic metabolism genes

  Active FNR represses aerobic metabolism genes under anoxic conditions.

  • DOI:10.1093/nar/gkad750 Fnr activates anaerobic metabolism genes and represses aerobic genes.
• cytochrome bd oxidase has high affinity for molecular oxygen

  Cytochrome bd is a high-affinity terminal oxidase enabling oxygen respiration at low O2.

  • DOI:10.1128/aem.00378-23 cytochrome bd supports high O2 consumption and high-affinity oxygen reduction at the cell surface.