bacillus shaped

Edge evidence

• MreB enables Rod complex RO:0002327

  MreB organizes rod-shape elongation machinery.

  • DOI:10.1146/annurev-cellbio-010521-010834 MreB filaments interact with Rod complexes Supports MreB-Rod complex interaction in rod-shape regulation.
• Rod complex directs peptidoglycan synthesis RO:0002211

  Rod complexes direct sidewall peptidoglycan synthesis.

  • DOI:10.1146/annurev-cellbio-010521-010834 Rod complexes drive cell wall insertion Supports Rod complex contribution to wall insertion.
• peptidoglycan synthesis produces lateral cell-wall elongation METPO:2000202

  Directed peptidoglycan synthesis supports cylindrical elongation.

  • DOI:10.1038/nrmicro2677 peptidoglycan synthesis to bacterial growth and morphology Supports regulated peptidoglycan synthesis as a determinant of bacterial morphology.
• lateral cell-wall elongation regulates bacillus shaped RO:0002211

  Lateral wall elongation maintains bacillus-like rod morphology.

  • DOI:10.1016/j.tim.2011.11.004 restores its rod shape Supports MreB-associated cell-wall synthesis as important for rod shape restoration and maintenance.
• FtsZ coordinates with peptidoglycan synthesis

  FtsZ coordinates division-associated peptidoglycan synthesis with rod-cell growth.

  • DOI:10.1038/nrmicro1205 FtsZ collaborates with penicillin binding proteins Supports FtsZ-PBP collaboration in bacterial cell-shape generation.
• peptidoglycan cell wall determines bacillus shaped

  The peptidoglycan cell wall protects against osmotic lysis and determines cell shape.

  • DOI:10.1038/s41467-023-39037-9 PG protects bacteria against osmotic lysis and determines cell shape.
• RodA-PBP2 synthase (Rod complex) required for bacterial cell elongation

  RodA-PBP2 is the essential synthase responsible for bacterial elongation.

  • DOI:10.1038/s41467-023-39037-9 RodA-PBP2 is an essential synthase responsible for bacterial elongation.
• circumferential glycan strand insertion gives rise to bacillus shaped

  Elongasome inserts long glycan strands as barrel-hoop reinforcement, giving rise to a rod-shaped cell.

  • DOI:10.1038/s41467-024-49785-x Inserts long glycan strands acting as barrel-hoop-like reinforcing structures, thereby giving rise to a rod-shaped cell.
• moenomycin inhibits class A penicillin-binding proteins RO:0002212

  Moenomycin inhibits class A penicillin-binding proteins, a family of PG synthases.

  • DOI:10.1038/s41467-023-41082-3 Moenomycin inhibits a family of PG synthases known as Class-A penicillin-binding proteins.
• RodZ causally upstream of, negative effect spherical cell morphology

  Loss of RodZ causes cells to become spherical, indicating RodZ maintains rod shape.

  • DOI:10.3389/fmicb.2024.1400434 delta-rodZ cells were spherical (WT cells are rod-shaped); RodZ broadly implicated in rod maintenance.