cell shape

Edge evidence

• peptidoglycan cell wall regulates cell shape RO:0002211

  The peptidoglycan wall has a primary role in maintaining bacterial cell shape.

  • DOI:10.1038/nrmicro1205 primary role in maintaining cell shape Review supports peptidoglycan wall as central to cell shape.
• penicillin-binding proteins catalyzes peptidoglycan synthesis biolink:catalyzes

  PBPs synthesize and remodel peptidoglycan during growth and division.

  • DOI:10.1038/nrmicro1205 carry out the reactions for synthesis and remodelling Supports PBPs in peptidoglycan synthesis/remodeling.
• peptidoglycan synthesis causes cell shape biolink:causes

  Spatial regulation of wall synthesis determines growth morphology.

  • DOI:10.1038/nrmicro2677 peptidoglycan synthesis to bacterial growth and morphology Review supports regulated peptidoglycan synthesis as a determinant of morphology.
• MreB positions peptidoglycan synthesis

  MreB helps organize or position peptidoglycan synthesis machinery.

  • DOI:10.1038/nrmicro2677 positions peptidoglycan biosynthesis machineries Supports MreB in spatial organization of cell-wall synthesis.
• FtsZ regulates cell shape RO:0002211

  FtsZ controls division-associated shape generation and septal wall synthesis.

  • DOI:10.1038/nrmicro1205 FtsZ is essential for cell division Supports FtsZ as a shape-related cytoskeletal protein through cell division.
• crescentin contributes to cell shape RO:0002326

  Crescentin contributes to curved-rod cell shape in representative bacteria.

  • DOI:10.1038/nrmicro1205 crescentin is required for the curved-rod shape Supports crescentin as a cell-shape determinant in Caulobacter.
• Rod complex (elongasome) shapes peptidoglycan architecture

  The rod complex (elongasome) determines the overall shape and dense architecture of peptidoglycan.

  • DOI:10.1002/mbo3.1385 Rod complex may be a determinant for the whole shape of peptidoglycan and its highly dense structure.
• peptidoglycan architecture regulates cell shape RO:0002211

  Peptidoglycan wall architecture underlies cell shape.

  • DOI:10.1002/mbo3.1385 Peptidoglycan determines cell shape (broad bacterial claim).
• MreB organizes rod shape

  MreB coordinates with PG synthases to organize cell-wall synthesis for rod shape.

  • DOI:10.1042/bsr20221664 MreB coordinates with PG synthases and is linked to rod shape.
• A22 (MreB inhibitor) disrupts rod shape

  A22 reduces MreB filaments, causing loss of rod shape and lysis.

  • DOI:10.1128/jb.00433-22 A22 reduces MreB filaments leading to loss of rod shape and lysis.
• cardiolipin / increased lipid order inhibits MreB RO:0002212

  Increased lipid order or cardiolipin interferes with MreB assembly.

  • DOI:10.1128/jb.00433-22 Increased lipid order or cardiolipin interferes with MreB assembly.
• flotillins promotes cell wall synthesis RO:0002213

  Flotillins promote MreB activity and cell-wall synthesis via membrane organization.

  • DOI:10.1128/jb.00433-22 Absence of flotillins downregulates MreB activity and cell wall synthesis.