coccobacillus shaped

Edge evidence

• MreB controls peptidoglycan synthesis RO:0002211

  MreB contributes to control of peptidoglycan synthetic complexes.

  • DOI:10.1128/JB.187.1.54-64.2005 control of the peptidoglycan synthetic complexes Supports MreB involvement in shape-related PG synthesis.
• peptidoglycan synthesis causes short-rod geometry biolink:causes

  Wall synthesis patterns determine whether cells remain rod-like or become short coccobacilli.

  • DOI:10.1128/JB.187.1.54-64.2005 conditions causing changes in cell shape Supports PG-associated shape changes to a coccobacillus state.
• septal growth contributes to short-rod geometry RO:0002326

  Division-associated septal growth contributes to the short-rod intermediate geometry.

  • DOI:10.1128/JB.187.1.54-64.2005 role at mid-cell ... in early septation Supports a septation-linked role for MreB in representative coccobacillus-forming cells.
• short-rod geometry produces coccobacillus shaped METPO:2000202

  Short-rod geometry produces the coccobacillus-shaped trait.

  • DOI:10.1128/JB.187.1.54-64.2005 from a rod to coccobacillus Supports the trait endpoint as a short-rod morphology.
• RodA/PBP3 elongasome increases cell length-to-width ratio RO:0002213

  Elongasome-driven lateral wall synthesis increases the long-to-short axis ratio, opposing a coccoid shape.

  • DOI:10.1128/mBio.03235-23 This elongation depends on the SEDS/PBP pair RodA/PBP3 and is seen as an increased ratio of long to short cell axes.
• cell length-to-width ratio determines short-rod geometry

  A reduced but non-coccoid length-to-width ratio defines the short-rod geometry of coccobacilli.

  • DOI:10.1128/mBio.03235-23 Long-to-short cell axis ratio quantifies the elongation state intermediate between coccus and rod.
• GpsB regulates PBP2 localization RO:0002211

  GpsB regulates the localization of PBP2 between cell periphery and division septum.

  • DOI:10.1128/mBio.03235-23 a gpsB mutant shows the strongest morphological phenotype, driven by partial delocalization of PBP2 and PBP4 away from the division septum.
• PBP2 localization controls peptidoglycan synthesis RO:0002211

  Spatial localization of PBP2 controls where peptidoglycan insertion and crosslinking occur, biasing cells toward elongation or rounding.

  • DOI:10.1128/mBio.03235-23 Increased PBP2/PBP4 at the cell periphery raises peptidoglycan insertion and crosslinking throughout the cell, impairing elongation.
• FtsZ filament properties directs peptidoglycan synthesis RO:0002211

  FtsZ filament geometry directs asymmetric, helical patterns of cell-wall insertion.

  • DOI:10.1128/mBio.00908-16 altered FtsZ filaments direct asymmetric, helical cell-wall insertion, generating elongation; this helical pattern of wall insertion leads to elongation.
• PBP2 (elongasome transpeptidase) required for short-rod geometry

  PBP2 transpeptidase activity within the RodA-PBP2 elongasome is required to maintain non-spherical rod/short-rod geometry.

  • DOI:10.1073/pnas.2215237120 Loss of RodA-PBP2 elongasome activity drives a rod-to-sphere transition; PBP2 transpeptidase activity is required for rod-shape maintenance.