branched shaped

Edge evidence

• DivIVA foci marks branch-site selection

  DivIVA foci mark sites where lateral branches will emerge.

  • DOI:10.1371/journal.pgen.1002423 mark sites of future branch outgrowth Supports DivIVA foci as branch-site markers.
• branch-site selection controls polarisome behavior RO:0002211

  Branch-site selection controls where new polar growth machinery is established.

  • DOI:10.1016/j.mib.2012.10.012 principal mechanism of branch site selection Supports branch-site selection as a regulated mechanism.
• polarisome behavior directs local cell-wall assembly RO:0002211

  Polarisome behavior directs local wall assembly at the branch site.

  • DOI:10.1016/j.mib.2012.10.012 modulate polar growth and hyphal branching Supports polarisome modulation of polar growth and branching.
• local cell-wall assembly regulates lateral branch outgrowth RO:0002211

  Local wall assembly drives emergence of the lateral branch.

  • DOI:10.1016/j.mib.2012.10.012 apical growth requires the localization of the machinery Supports localized wall-building machinery as needed for apical branch outgrowth.
• lateral branch outgrowth manifests as branched shaped METPO:2007400

  Lateral branch outgrowth manifests the branched-shape phenotype.

  • DOI:10.1016/j.mib.2012.10.012 initiation of new branches Supports branched morphology as a Streptomyces growth phenotype.
• DivIVA polarisome splitting causes lateral branch outgrowth biolink:causes

  Polarisome splitting at growing tips generates daughter polarisomes that coordinate new lateral branch emergence.

  • DOI:10.1093/femsml/uqad020 Splitting of polarisomes at growing tips generates daughter polarisomes that coordinate emergence of new lateral branches upon reaching a critical size.
• DivIVA/Scy/FilP polarisome localizes localization of peptidoglycan synthases and hydrolases to the apex

  The DivIVA/Scy/FilP polarisome localizes peptidoglycan synthases and hydrolases to the apex.

  • DOI:10.1128/mbio.01492-24 The polarisome composed of DivIVA with Scy and FilP localizes cell-wall enzymes to one pole, linking polarity establishment to branching.
• AfsK-mediated DivIVA phosphorylation stimulates multiple new polarisomes and hyperbranching

  AfsK-mediated DivIVA phosphorylation disassembles the apical polarisome and stimulates multiple new polarisomes.

  • DOI:10.1093/femsml/uqad020 Constitutive AfsK activity/high DivIVA phosphorylation disassembles the apical polarisome and stimulates multiple new polarisomes, producing a hyperbranching phenotype.
• SppA dephosphorylation of DivIVA opposes multiple new polarisomes and hyperbranching

  SppA dephosphorylation of DivIVA opposes AfsK-driven hyperbranching, defining a reversible branching-control circuit.

  • DOI:10.1093/femsml/uqad020 AfsK phosphorylates DivIVA in response to bacitracin/vancomycin stress, while SppA dephosphorylates DivIVA, defining a reversible branching-control circuit.
• cell-wall stress (bacitracin/vancomycin) activates AfsK-mediated DivIVA phosphorylation RO:0002213

  Cell-wall stress activates AfsK-dependent DivIVA phosphorylation.

  • DOI:10.1093/femsml/uqad020 AfsK phosphorylates DivIVA in response to cell-wall stress (e.g., bacitracin, vancomycin).
• StlP membrane microdomain formation enables proper polar growth and normal branch spacing RO:0002327

  StlP membrane microdomain formation enables proper polar growth and normal branch spacing.

  • DOI:10.1038/s41467-025-58093-x Loss of StlP leads to branching of filaments; constitutive stlP expression notably reduces lateral branching and increases tip-to-branch distance.