sarcina arrangement

Edge evidence

• three perpendicular division planes causes sarcina arrangement biolink:causes

  Three perpendicular division planes with incomplete separation yield cubic eight-cell packets.

  • DOI:10.1038/ncomms4842 Three-plane division with incomplete daughter-cell separation yields cubic eight-cell packets.
• cell division enables sarcina arrangement RO:0002327

  Bacterial cell division underlies sarcina packet formation.

  • DOI:10.1128/MMBR.00001-06 Young treats the sarcina cubic packet as a division-plane-determined coccal arrangement.
• FtsZ polymerizes to form Z ring

  FtsZ polymerizes to form the dynamic Z ring at the division site.

  • DOI:10.1002/mbo3.1338 FtsZ polymerizes to form a dynamic structure known as the Z ring; broadly conserved bacterial/coccal mechanism.
• FtsA attaches Z ring

  FtsA tethers the Z ring to the cytoplasmic membrane for proper divisome assembly.

  • DOI:10.1002/mbo3.1338 Proper Z ring assembly requires attachment to the cytoplasmic membrane via interactions with FtsA; general divisome mechanism.
• FtsA attaches Z ring to cytoplasmic membrane

  FtsA attaches the Z ring to the cytoplasmic membrane.

  • DOI:10.1002/mbo3.1338 Z ring attachment to the cytoplasmic membrane occurs via interactions with FtsA.
• peptidoglycan synthetases and hydrolases cooperate in septal peptidoglycan remodeling

  PG synthetases and hydrolases work together to build the septal cross-wall.

  • DOI:10.1002/mbo3.1338 PG synthetases and hydrolases work together to incorporate new PG into the existing mesh and to make the septal cross wall; general cell-wall remodeling principle.
• cell wall synthesis at division site drives division septum formation

  FtsZ-dependent cell wall synthesis at the division site drives septum formation.

  • DOI:10.1111/j.1574-6976.2007.00098.x FtsZ-dependent cell wall synthesis is predominant; coccal cell wall synthesis occurs mainly at the division site, driving septation.
• peptidoglycan hydrolases degrade peripheral peptidoglycan bridge

  Peptidoglycan hydrolases degrade the peripheral PG bridge connecting daughter cells.

  • DOI:10.1002/mbo3.1338 Hydrolases likely trigger cell splitting by degrading the peripheral bridge, not the entire septum; general separation mechanism.
• peripheral peptidoglycan bridge degradation triggers daughter-cell separation

  Degradation of the peripheral PG bridge triggers daughter-cell splitting; incomplete separation retains packets.

  • DOI:10.1002/mbo3.1338 Degradation of the peripheral PG bridge, together with mechanical factors, results in a sudden crack that separates the cells; regulated/incomplete separation determines packet retention.