staphylococcus arrangement

Edge evidence

• multi-plane non-orthogonal division causes staphylococcus arrangement biolink:causes

  Multi-plane non-orthogonal division with incomplete separation generates 3D coccal clusters.

  • DOI:10.1038/ncomms4842 Division-plane orientation and daughter-cell separation govern formation of three-dimensional coccal clusters.
• cell division enables staphylococcus arrangement RO:0002327

  Bacterial cell division underlies coccal cluster formation.

  • DOI:10.1128/MMBR.00001-06 Young treats clustered coccal arrangement as a division-plane- determined heritable morphology.
• FacZ prevents aberrant placement of FtsZ Z-ring

  FacZ prevents aberrant membrane invaginations and multiple/mispositioned FtsZ cytokinetic rings.

  • DOI:10.1038/s41564-024-01607-y "Inactivation of FacZ produced aberrant membrane invaginations and multiple FtsZ cytokinetic rings"; peer-reviewed S. aureus phenotype.
• FacZ interacts with GpsB biolink:interacts_with

  FacZ directly interacts with the division regulator GpsB.

  • DOI:10.1038/s41564-024-01607-y "FacZ interacts directly with GpsB both in vitro and in vivo"; direct biochemical and cellular interaction.
• FacZ antagonizes GpsB

  FacZ antagonizes GpsB to prevent spurious Z-ring formation and aberrant envelope invaginations.

  • DOI:10.1038/s41564-024-01607-y Authors propose FacZ antagonizes GpsB to prevent spurious Z-ring formation; peer-reviewed proposed model.
• GpsB promotes lateral interactions between FtsZ

  GpsB promotes lateral interactions between FtsZ filaments.

  • DOI:10.1038/s41564-024-01607-y "GpsB itself interacts with FtsZ and promotes lateral interactions between FtsZ filaments."
• FtsZ Z-ring organizes divisome peptidoglycan synthesis at division site

  Treadmilling FtsZ Z-ring organizes the divisome peptidoglycan synthesis machinery at the division site.

  • DOI:10.1038/s41564-024-01607-y "the septum is built by the divisome organized by treadmilling FtsZ polymers that form a dynamic Z-ring to establish the division site."